Renoprotective Mono- and Triterpenoids from the Fruit of Gardenia jasminoides

This paper describes the isolation and characterization of 17 new and 12 known terpenoids from the fruit of Gardenia jasminoides. The structures of eight new triterpenoids and nine new monoterpenoids, including their absolute configurations, were defined by spectroscopic analysis in combination of q...

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Published inJournal of natural products (Washington, D.C.) Vol. 83; no. 4; pp. 1118 - 1130
Main Authors Cao, Yan-Gang, Zhang, Yan-Li, Zeng, Meng-Nan, Qi, Man, Ren, Ying-Jie, Liu, Yan-Ling, Zhao, Xuan, Zheng, Xiao-Ke, Feng, Wei-Sheng
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 24.04.2020
Amer Chemical Soc
Subjects
Animals
Chemistry, Medicinal
Circular Dichroism
Fruit - chemistry
Gardenia - chemistry
Life Sciences & Biomedicine
Lipopolysaccharides - chemistry
Magnetic Resonance Spectroscopy
Monoterpenes - analysis
Monoterpenes - chemistry
Pharmacology & Pharmacy
Plant Sciences
Rats
Science & Technology
Terpenes - analysis
Terpenes - chemistry
Triterpenes - analysis
Triterpenes - chemistry
Triterpenes - isolation & purification
MONOTERPENOIDS
GLYCOSIDES
ACUTE KIDNEY INJURY
ACID
MORUS-ALBA L
INFLAMMATION
LEAVES
ROOT BARK
DERIVATIVES
PHENOLIC CONSTITUENTS
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Summary:This paper describes the isolation and characterization of 17 new and 12 known terpenoids from the fruit of Gardenia jasminoides. The structures of eight new triterpenoids and nine new monoterpenoids, including their absolute configurations, were defined by spectroscopic analysis in combination of quantum chemical electronic circular dichroism (ECD), vibrational circular dichroism (VCD), and gauge-independent atomic orbital (GIAO) NMR calculations. The cytoprotective effects of the isolated compounds against lipopolysaccharide (LPS)-induced apoptosis in normal rat kidney tubule epithelioid (NRK 52e) cells were investigated in vitro. Compounds 10, 18, 20, 21, 24, and 26 exhibited significant protective effects with EC50 values from 14.2 nM to 1.6 μM.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.9b01119