Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes

• Published in: Journal of natural products (Washington, D.C.) Vol. 87; no. 2; pp. 297 - 303
• Main Authors: Fu, Quan, Yuan, Jing, Yang, Tie-Hua, Su, Jin-Hao, Zhang, Jing-Jing, Wu, Xue-Wen, Zhang, Hong-Ye, Xiao, Wei-Lie, Zheng, Chang-Bo, Li, Xiao-Li
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 23.02.2024; Amer Chemical Soc
• Subjects: Animals; Chemistry, Medicinal; Life Sciences & Biomedicine; Molecular Structure; Myocytes, Cardiac; Pharmacology & Pharmacy; Phellinus; Plant Sciences; Polycyclic Sesquiterpenes; Rats; Science & Technology; Sesquiterpenes - chemistry

Three nor-sesquiterpenes, phellinharts A–C (1–3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1–3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogen...