Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes

Three nor-sesquiterpenes, phellinharts A–C (1–3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1–3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogen...

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Published inJournal of natural products (Washington, D.C.) Vol. 87; no. 2; pp. 297 - 303
Main Authors Fu, Quan, Yuan, Jing, Yang, Tie-Hua, Su, Jin-Hao, Zhang, Jing-Jing, Wu, Xue-Wen, Zhang, Hong-Ye, Xiao, Wei-Lie, Zheng, Chang-Bo, Li, Xiao-Li
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 23.02.2024
Amer Chemical Soc
Subjects
Animals
Chemistry, Medicinal
Life Sciences & Biomedicine
Molecular Structure
Myocytes, Cardiac
Pharmacology & Pharmacy
Phellinus
Plant Sciences
Polycyclic Sesquiterpenes
Rats
Science & Technology
Sesquiterpenes - chemistry
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Summary:Three nor-sesquiterpenes, phellinharts A–C (1–3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1–3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogenic pathways involving demethylation, ring cleavage, and rearrangement were proposed. Compounds 1–3 displayed potent anti-hypertrophic activities with low cytotoxicity (CC50 > 50 μM) in rat cardiomyocytes, underscoring their therapeutic potential.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.3c00985