Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes

Three nor-sesquiterpenes, phellinharts A–C (1–3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1–3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogen...

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Published inJournal of natural products (Washington, D.C.) Vol. 87; no. 2; pp. 297 - 303
Main Authors Fu, Quan, Yuan, Jing, Yang, Tie-Hua, Su, Jin-Hao, Zhang, Jing-Jing, Wu, Xue-Wen, Zhang, Hong-Ye, Xiao, Wei-Lie, Zheng, Chang-Bo, Li, Xiao-Li
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 23.02.2024
Amer Chemical Soc
Subjects
Animals
Chemistry, Medicinal
Life Sciences & Biomedicine
Molecular Structure
Myocytes, Cardiac
Pharmacology & Pharmacy
Phellinus
Plant Sciences
Polycyclic Sesquiterpenes
Rats
Science & Technology
Sesquiterpenes - chemistry
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Abstract Three nor-sesquiterpenes, phellinharts A–C (1–3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1–3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogenic pathways involving demethylation, ring cleavage, and rearrangement were proposed. Compounds 1–3 displayed potent anti-hypertrophic activities with low cytotoxicity (CC50 > 50 μM) in rat cardiomyocytes, underscoring their therapeutic potential.
AbstractList Three nor-sesquiterpenes, phellinharts A-C (1-3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1-3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogenic pathways involving demethylation, ring cleavage, and rearrangement were proposed. Compounds 1-3 displayed potent anti-hypertrophic activities with low cytotoxicity (CC50 > 50 μM) in rat cardiomyocytes, underscoring their therapeutic potential.
Three nor-sesquiterpenes, phellinharts A-C ( - ), isolated from , exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds - were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogenic pathways involving demethylation, ring cleavage, and rearrangement were proposed. Compounds - displayed potent anti-hypertrophic activities with low cytotoxicity (CC > 50 μM) in rat cardiomyocytes, underscoring their therapeutic potential.
Three nor-sesquiterpenes, phellinharts A-C (1-3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1-3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogenic pathways involving demethylation, ring cleavage, and rearrangement were proposed. Compounds 1-3 displayed potent anti-hypertrophic activities with low cytotoxicity (CC50 > 50 mu M) in rat cardiomyocytes, underscoring their therapeutic potential.
Author Li, Xiao-Li
Zhang, Jing-Jing
Yang, Tie-Hua
Zheng, Chang-Bo
Xiao, Wei-Lie
Wu, Xue-Wen
Yuan, Jing
Zhang, Hong-Ye
Fu, Quan
Su, Jin-Hao
AuthorAffiliation Yunnan University of Chinese Medicine
Kunming Medical University, and Yunnan Vaccine Laboratory
Southwest United Graduate School
School of Chinese Materia Medica
Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan
School of Pharmaceutical Science, Yunnan Key Laboratory of Pharmacology for Natural Products
Yunnan University
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Snippet Three nor-sesquiterpenes, phellinharts A–C (1–3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The...
Three nor-sesquiterpenes, phellinharts A-C (1-3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The...
Three nor-sesquiterpenes, phellinharts A-C ( - ), isolated from , exhibited unprecedented protoilludane and cerapicane-type structures. The structures of...
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SubjectTerms Animals
Chemistry, Medicinal
Life Sciences & Biomedicine
Molecular Structure
Myocytes, Cardiac
Pharmacology & Pharmacy
Phellinus
Plant Sciences
Polycyclic Sesquiterpenes
Rats
Science & Technology
Sesquiterpenes - chemistry
Title Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes
URI http://dx.doi.org/10.1021/acs.jnatprod.3c00985
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https://www.ncbi.nlm.nih.gov/pubmed/38308643
https://search.proquest.com/docview/2929131622
Volume 87
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