Trigoflavidols A–C, Degraded Diterpenoids with Antimicrobial Activity, from Trigonostemon flavidus

• Published in: Journal of natural products (Washington, D.C.) Vol. 75; no. 5; pp. 996 - 1000
• Main Authors: Tang, Gui-Hua, Zhang, Yu, Gu, Yu-Cheng, Li, Shi-Fei, Di, Ying-Tong, Wang, Yue-Hu, Yang, Cui-Xian, Zuo, Guo-Ying, Li, Shun-Lin, He, Hong-Ping, Hao, Xiao-Jiang
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 25.05.2012; Amer Chemical Soc
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Chemistry, Medicinal; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; Euphorbiaceae - chemistry; Humans; Life Sciences & Biomedicine; Methicillin-Resistant Staphylococcus aureus - drug effects; Microbial Sensitivity Tests; Molecular Structure; Pharmacology & Pharmacy; Plant Sciences; Plant Stems - chemistry; Science & Technology; Staphylococcus aureus; Staphylococcus aureus - drug effects; DAPHNANE; PLANT; CONSTITUENTS
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np3001128

Trigoflavidols A (1) and B (2), tetranorditerpenoid dimers possessing a rearrangement skeleton with a spiroketal core moiety, and trigoflavidol C (3), a hexanorditerpenoid, have been isolated from Trigonostemon flavidus along with two known compounds. Compounds 1 and 2 showed moderate antimicrobial activities (MIC values: 3.12–6.25 μg/mL) against Staphylococcus aureus, 8#MRSA, and 82#MRSA, and 1, 2, and 5 showed weak activities (IC50 values: 3.75–28.99 μM) against various human tumor cell lines.