Facile Preparation of N‑Vinylisobutyramide and N‑Vinyl-2-pyrrolidinone

A facile synthesis of N-vinylakylamides from commercially available N-vinylformamide and corresponding acyl chlorides was developed and exemplified by the preparation of N-vinylisobutyramide (NVIBA) and N-vinyl-2-pyrrolidinone (NVP) in high yields (80–89%). Both NVIBA and NVP are valuable monomers f...

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Bibliographic Details
Published inOrganic process research & development Vol. 19; no. 12; pp. 2045 - 2049
Main Authors Tu, Siyu, Zhang, Chunming
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.12.2015
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Applied
Chemistry, Organic
Physical Sciences
Science & Technology
TEMPERATURE
IMIDES
POLY(N-VINYLALKYLAMIDE)
FUNCTIONALITIES
VINYLATION
ENAMIDES
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Summary:A facile synthesis of N-vinylakylamides from commercially available N-vinylformamide and corresponding acyl chlorides was developed and exemplified by the preparation of N-vinylisobutyramide (NVIBA) and N-vinyl-2-pyrrolidinone (NVP) in high yields (80–89%). Both NVIBA and NVP are valuable monomers for water-soluble polymers with an array of applications in personal care, pharmaceutical, agricultural, and industrial products.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.5b00303