Arene Ruthenium Catalyst MCAT-53 for the Synthesis of Heterobiaryl Compounds in Water through Aromatic C–H Bond Activation

A new water friendly MCAT-53 [Ru2Cl2 (HCOO)3(p-cymene)] Na (sodium η-6-p-cymene dichloro diruthenium triformato complex) has been developed as a catalyst to effect aromatic C–H bond activation and C–C coupling reactions in water. Cross-coupling reactions were performed in DI/distilled water under ai...

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Bibliographic Details
Published inOrganic process research & development Vol. 22; no. 9; pp. 1119 - 1130
Main Authors Mehta, Anita, Saha, Biswajit, Koohang, Ali Aiden, Chorghade, Mukund S
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 21.09.2018
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Applied
Chemistry, Organic
Physical Sciences
Science & Technology
C−H activation
C−C coupling
ruthenium catalyst
MCAT-53
C-C coupling
FUNCTIONALIZATION
CROSS-COUPLING REACTIONS
CARBOXYLATE
C-H activation
PHENOLS
REACTIVITY
OLEFIN METATHESIS
ARYL
DIRECT ARYLATIONS
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Summary:A new water friendly MCAT-53 [Ru2Cl2 (HCOO)3(p-cymene)] Na (sodium η-6-p-cymene dichloro diruthenium triformato complex) has been developed as a catalyst to effect aromatic C–H bond activation and C–C coupling reactions in water. Cross-coupling reactions were performed in DI/distilled water under air- and ligand-free conditions without further activation of the catalyst. Synthesis of an advanced intermediate of CETP inhibitor, Anacetrapib, in water has been demonstrated to give a single regioisomer using the MCAT-53 catalyst.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.8b00141