Thiazide diuretic therapy and chronic photosensitivity

Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients. These patients developed a debilitating photosensitivity that persisted for months to years even after they stopped taking the diuretic. Their age range was 44 to 66 years. Phototesting with ultraviolet...

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Bibliographic Details
Published inArchives of dermatology (1960) Vol. 121; no. 4; p. 522
Main Authors Robinson, H N, Morison, W L, Hood, A F
Format Journal Article
LanguageEnglish
Published United States 01.04.1985
Subjects
Adult
Aged
Chronic Disease
Female
Humans
Hydrochlorothiazide - adverse effects
Male
Middle Aged
Photosensitivity Disorders - chemically induced
Photosensitivity Disorders - drug therapy
Photosensitivity Disorders - pathology
PUVA Therapy
Skin - pathology
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Summary:Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients. These patients developed a debilitating photosensitivity that persisted for months to years even after they stopped taking the diuretic. Their age range was 44 to 66 years. Phototesting with ultraviolet B (UV-B) and ultraviolet A (UV-A) radiation revealed decreased minimal erythemal doses for one or both wave bands in all patients tested. Histologic examination of skin biopsy specimens from the patients' UV-B and UV-A test sites and lesional skin revealed an acute eczematous dermatitis. Treatment with methoxsalen and UV-A radiation successfully cleared the photosensitive eruption in the patients.
ISSN:0003-987X
DOI:10.1001/archderm.1985.01660040106021