Visible Light Photocatalysis: Applications and New Disconnections in the Synthesis of Pharmaceutical Agents

Photoredox catalysis has emerged as a powerful tool for the synthetic chemist to access challenging targets and to generate new structural complexity. This review focuses on the application of this mode of catalysis to arrive at known pharmaceutically active compounds. Within this setting, the growi...

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Bibliographic Details
Published inOrganic process research & development Vol. 20; no. 7; pp. 1134 - 1147
Main Authors Douglas, James J, Sevrin, Martin J, Stephenson, Corey R. J
Format Journal Article
LanguageEnglish
Published American Chemical Society 15.07.2016
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Summary:Photoredox catalysis has emerged as a powerful tool for the synthetic chemist to access challenging targets and to generate new structural complexity. This review focuses on the application of this mode of catalysis to arrive at known pharmaceutically active compounds. Within this setting, the growing synergy with other modes of catalysis, such as nickel/photoredox dual catalysis, as well as pioneering examples utilizing continuous flow to transition photoredox catalysis to preparative scale will be highlighted.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.6b00125