Identification and Synthesis of an Oxidation Product of Tilmicosin
During formulation development of the veterinary macrolide antibiotic tilmicosin, an oxidation product of the parent molecule was identified. Use of liquid chromatography/mass spectrometry and nuclear magnetic resonance spectroscopy characterized the structure as 12,13-epoxytilmicosin, resulting fro...
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Published in | Journal of agricultural and food chemistry Vol. 46; no. 8; pp. 3265 - 3271 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
17.08.1998
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | During formulation development of the veterinary macrolide antibiotic tilmicosin, an oxidation product of the parent molecule was identified. Use of liquid chromatography/mass spectrometry and nuclear magnetic resonance spectroscopy characterized the structure as 12,13-epoxytilmicosin, resulting from the oxidation of the double bond at the 12,13-position of the macrolide dienone. The synthesis of this oxidation product for confirmation of structural identity is described. The synthetic compound was identical to the isolated oxidation product, 12,13-epoxytilmicosin. Keywords: Tilmicosin; epoxytilmicosin; macrolide; oxidation; synthesis; liquid chromatography/ion spray mass spectrometry |
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Bibliography: | L70 1999001289 istex:4C5F57EF1040A7F749B41678787E04D81FEA7836 ark:/67375/TPS-QR3KBVXB-0 |
ISSN: | 0021-8561 1520-5118 |
DOI: | 10.1021/jf9710746 |