The 25th Anniversary of the Buchwald–Hartwig Amination: Development, Applications, and Outlook

• Published in: Organic process research & development Vol. 23; no. 8; pp. 1478 - 1483
• Main Authors: Forero-Cortés, Paola A, Haydl, Alexander M
• Format: Journal Article
• Language: English
• Published: American Chemical Society 16.08.2019
• Subjects: Buchwald−Hartwig amination; amine synthesis; carbon−nitrogen coupling; methodology; rational ligand design

The palladium-catalyzed cross-coupling of amines and aryl (pseudo)­halides, now commonly known as the Buchwald–Hartwig amination, was first reported 25 years ago. Since the simultaneous breakthrough reports of Buchwald and Hartwig in 1995, this reaction has transformed the way synthetic chemists thi...