The 25th Anniversary of the Buchwald–Hartwig Amination: Development, Applications, and Outlook

The palladium-catalyzed cross-coupling of amines and aryl (pseudo)­halides, now commonly known as the Buchwald–Hartwig amination, was first reported 25 years ago. Since the simultaneous breakthrough reports of Buchwald and Hartwig in 1995, this reaction has transformed the way synthetic chemists thi...

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Bibliographic Details
Published inOrganic process research & development Vol. 23; no. 8; pp. 1478 - 1483
Main Authors Forero-Cortés, Paola A, Haydl, Alexander M
Format Journal Article
LanguageEnglish
Published American Chemical Society 16.08.2019
Subjects
Buchwald−Hartwig amination
amine synthesis
carbon−nitrogen coupling
methodology
rational ligand design
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Summary:The palladium-catalyzed cross-coupling of amines and aryl (pseudo)­halides, now commonly known as the Buchwald–Hartwig amination, was first reported 25 years ago. Since the simultaneous breakthrough reports of Buchwald and Hartwig in 1995, this reaction has transformed the way synthetic chemists think about synthesizing aromatic amines. In this highlight article, a short showcasing discussion about the genesis of this reaction is provided, along with selected examples showing the impact of this transformation in synthetic chemistry in both academic and industrial settings.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.9b00161