KB343, a Cyclic Tris-guanidine Alkaloid from Palauan Zoantharian Epizoanthus illoricatus

A new tris-guanidine alkaloid, KB343 (1), was isolated from the aqueous extract of a Palauan zoantharian, Epizoanthus illoricatus. The structure of 1 was determined on the basis of spectral analyses of 1 and its derivatives. The absolute configuration for 1 was determined upon comparison of the CD s...

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Bibliographic Details
Published inOrganic letters Vol. 20; no. 10; pp. 3039 - 3043
Main Authors Matsumura, Ken, Taniguchi, Tohru, Reimer, James D, Noguchi, Shuntaro, Fujita, Masaki J, Sakai, Ryuichi
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.05.2018
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PARAZOANTHUS-AXINELLAE
BROMOPYRROLE ALKALOIDS
NATURAL-PRODUCTS
BIOLOGY
CHEMISTRY
AGELAS
ZOANTHOXANTHINS
INHIBITOR
MARINE
DERIVATIVES
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Summary:A new tris-guanidine alkaloid, KB343 (1), was isolated from the aqueous extract of a Palauan zoantharian, Epizoanthus illoricatus. The structure of 1 was determined on the basis of spectral analyses of 1 and its derivatives. The absolute configuration for 1 was determined upon comparison of the CD spectrum of 1 to those obtained from density functional theory calculations. The structure of 1 is highly unusual, as three guanidine groups are present in one ring system.
Bibliography:ObjectType-Article-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b01069