Palladium-Catalyzed Carbonylative Sonogashira/Annulation Reaction: Synthesis of Indolo[1,2‑b]isoquinolines

A palladium-catalyzed carbonylative Sonogashira/annulation reaction for the synthesis of indolo­[1,2-b]­isoquinolines has been developed. Tetracyclic 6/5/6/6 indoline skeletons were synthesized in moderate to good yields from easily available 2-bromo-N-(2-iodophenyl)­benzamides and terminal alkynes....

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Published inOrganic letters Vol. 24; no. 5; pp. 1201 - 1206
Main Authors Li, Lin, Liu, Xin-Lian, Qi, Zhuang, Yang, Ai-Hua, Ma, Ai-Jun, Peng, Jin-Bao
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 11.02.2022
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Summary:A palladium-catalyzed carbonylative Sonogashira/annulation reaction for the synthesis of indolo­[1,2-b]­isoquinolines has been developed. Tetracyclic 6/5/6/6 indoline skeletons were synthesized in moderate to good yields from easily available 2-bromo-N-(2-iodophenyl)­benzamides and terminal alkynes. Notably, this efficient methodology established three C–C bonds and a C–N bond through a one-step transformation and provided a new method for the synthesis of indolo­[1,2-b]­isoquinoline derivatives.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c04350