Tuberindine A, a Truffle Alkaloid with an Unprecedented Skeleton Exhibiting Anti-hyperuricemic Bioactivity

Tuberindines A and B (1 and 2), truffle alkaloids with intriguing structures, were isolated from Tuber indicum and detected in other truffle species. They appear to arise biosynthetically from amino acid and isosaccharinic units. Compound 1 upregulated the expression of organic anion transporters OA...

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Published inOrganic letters Vol. 24; no. 24; pp. 4333 - 4337
Main Authors Zhao, Lan-Qin, Zhao, Yun-Li, He, Ying-Jie, Yang, Xing-Wei, Luo, Xiao-Dong
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 24.06.2022
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Summary:Tuberindines A and B (1 and 2), truffle alkaloids with intriguing structures, were isolated from Tuber indicum and detected in other truffle species. They appear to arise biosynthetically from amino acid and isosaccharinic units. Compound 1 upregulated the expression of organic anion transporters OAT1 and ABCG2 and significantly exhibited antihyperuricemic bioactivity in vitro and in vivo, which might support the value of truffles as a dietary supplement.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c01421