Fe-Catalyzed Difunctionalization of Aryl Titanates Enabled by Fe/Ti Synergism

Fe-catalyzed difunctionalization of aryl titanates via double C–H activation has been developed, where aryl titanates were arylated via ortho C–H activation, followed by ipso electrophilic trapping of the C–Ti bond. The ortho C–H arylation should be promoted by a 1,2-Fe/Ti synergistic heterobimetall...

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Bibliographic Details
Published inOrganic letters Vol. 25; no. 15; pp. 2745 - 2749
Main Authors Wei, Yi-Ming, Ma, Xiao-Di, Wang, Meng-Fei, Duan, Xin-Fang
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 21.04.2023
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
SERIES
BOND
C-H ACTIVATION
COMPLEXES
ARYLATION
ESTERS
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Summary:Fe-catalyzed difunctionalization of aryl titanates via double C–H activation has been developed, where aryl titanates were arylated via ortho C–H activation, followed by ipso electrophilic trapping of the C–Ti bond. The ortho C–H arylation should be promoted by a 1,2-Fe/Ti synergistic heterobimetallic arylene intermediate and represents an ortho C–H ferration directed by a readily transformable C–Ti group. Common benzamides, esters, and nitriles function as arylating reagents, which involves another ortho C–H activation directed by these functionalities.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c00975