Palladium-Promoted DNA-Compatible Heck Reaction

Optimal conditions for palladium-promoted Heck reaction on DNA were developed with good to excellent conversions. Versatility with either DNA-conjugated styrene/acrylamide or aryl iodide and a broad substrate scope of the corresponding coupling partners were established. Furthermore, robustness of t...

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Bibliographic Details
Published inOrganic letters Vol. 21; no. 3; pp. 719 - 723
Main Authors Wang, Xuan, Sun, Hui, Liu, Jiaxiang, Zhong, Wenge, Zhang, Mingqiang, Zhou, Hu, Dai, Dongcheng, Lu, Xiaojie
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 01.02.2019
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
SYSTEM
ENCODED CHEMICAL LIBRARIES
COUPLING REACTIONS
ACRYLIC-ACID
SELECTION
CATALYZED HECK
WATER
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Summary:Optimal conditions for palladium-promoted Heck reaction on DNA were developed with good to excellent conversions. Versatility with either DNA-conjugated styrene/acrylamide or aryl iodide and a broad substrate scope of the corresponding coupling partners were established. Furthermore, robustness of the Heck reaction conditions on single-strand DNA and feasibility for DNA-encoded library production were demonstrated.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b03926