Discovery of Glycosyltransferases Involved in the Biosynthesis of Ligupurpuroside B

In this study, we report the characterization of three glycosyltransferases involved in the biosynthesis of ligupurpuroside B, a complex acylated phenolic glycoside in Ligustrum robustum. UGT85AF8 catalyzed the formation of salidroside from tyrosol. UGT79G7, an osmanthuside A 1,3-rhamnosyltransferas...

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Published inOrganic letters Vol. 23; no. 20; pp. 7851 - 7854
Main Authors Yang, Yihan, Wu, Yanan, Zhuang, Yibin, Liu, Tao
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 15.10.2021
Subjects
Bacterial Proteins - biosynthesis
Bacterial Proteins - chemistry
Glucosides - chemistry
Glycosides - biosynthesis
Glycosides - chemistry
Glycosyltransferases - chemistry
Hexosyltransferases - biosynthesis
Hexosyltransferases - chemistry
Molecular Structure
Phenols - chemistry
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - chemistry
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Summary:In this study, we report the characterization of three glycosyltransferases involved in the biosynthesis of ligupurpuroside B, a complex acylated phenolic glycoside in Ligustrum robustum. UGT85AF8 catalyzed the formation of salidroside from tyrosol. UGT79G7, an osmanthuside A 1,3-rhamnosyltransferase, and UGT79A19, an osmanthuside B 1,4-rhamnosyltransferase, sequentially converted osmanthuside A into ligupurpuroside B. Orthologs of UGT79G7 were also discovered from other plants producing verbascoside. These rhamnosyltransferases expand the toolbox for the biosynthesis of natural products with various sugar chains.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c02873