Streptoglycerides A–D with a Rare 6/5/5 Tricyclic Ring Skeleton from a Marine Actinomycete Streptomyces species

Four novel secondary metabolites possessing a unique 6/5/5 tricyclic ring system, streptoglycerides A–D (1–4), were isolated from a marine actinomycete Streptomyces sp. derived from a mangrove sample collected on Kosrae Island. Their structures and absolute configurations were elucidated by spectros...

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Published inOrganic letters Vol. 20; no. 19; pp. 6037 - 6040
Main Authors Choi, Byeoung-Kyu, Park, Shin-Young, Choi, Dong-Kug, Shin, Bora, Shin, Yern-Hyerk, Oh, Dong-Chan, Lee, Hwa-Sun, Lee, Hyi-Seung, Lee, Yeon-Ju, Lee, Jong Seok, Lee, Ji Hoon, Shin, Hee Jae
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 05.10.2018
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Cyclization
Glycerides - chemistry
Models, Molecular
Molecular Conformation
Physical Sciences
Science & Technology
Streptomyces - chemistry
MICROGLIA
NATURAL-PRODUCTS
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Summary:Four novel secondary metabolites possessing a unique 6/5/5 tricyclic ring system, streptoglycerides A–D (1–4), were isolated from a marine actinomycete Streptomyces sp. derived from a mangrove sample collected on Kosrae Island. Their structures and absolute configurations were elucidated by spectroscopic data and electronic circular dichroism data. Streptoglyceride C (3) showed a weak inhibitory effect on the production of nitric oxide in BV-2 microglia cells.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b02411