A Dual-Protein Cascade Reaction for the Regioselective Synthesis of Quinoxalines

In this work, an efficient dual-protein (lipase and hemoglobin) system was successfully constructed for the regioselective synthesis of quinoxalines in water. A set of quinoxalines were obtained in high yields under optimal reaction conditions. This dual-protein method exhibited a regioselectivity h...

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Published inOrganic letters Vol. 22; no. 10; pp. 3900 - 3904
Main Authors Li, Fengxi, Tang, Xuyong, Xu, Yaning, Wang, Chunyu, Wang, Zhi, Li, Zhengqiang, Wang, Lei
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 15.05.2020
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
HEMOGLOBIN
OXIDATION
DESIGN
PROMISCUITY
ANNULATION
CATALYZED SYNTHESIS
BIOLOGICAL EVALUATION
EFFICIENT
ALKYNE
WATER
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Summary:In this work, an efficient dual-protein (lipase and hemoglobin) system was successfully constructed for the regioselective synthesis of quinoxalines in water. A set of quinoxalines were obtained in high yields under optimal reaction conditions. This dual-protein method exhibited a regioselectivity higher than those of previously reported methods. This study not only provides a green and mild strategy for the synthesis of quinoxalines but also expands the application of lipase and hemoglobin in organic synthesis.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c01186