Brominated and Sulfur-Containing Angucyclines Derived from a Single Pathway: Identification of Nocardiopsistins D–F

One novel brominated nocardiopsistin D (1) and two new sulfur-containing nocardiopsistins E–F (2–3) were identified from Nocardiopsis sp. HB-J378. The biosynthetic gene cluster ncd featuring a brominase was identified. Compounds 1–3 exhibited significant anti-methicillin-resistant Staphylococcus aur...

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Bibliographic Details
Published inOrganic letters Vol. 24; no. 43; pp. 7900 - 7904
Main Authors Xu, Dongbo, Metz, Jackie, Harmody, Dedra, Peterson, Tara, Winder, Priscilla, Guzmán, Esther A., Russo, Riccardo, McCarthy, Peter J., Wright, Amy E., Wang, Guojun
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 04.11.2022
Subjects
Anti-Bacterial Agents - pharmacology
Methicillin-Resistant Staphylococcus aureus
Microbial Sensitivity Tests
Staphylococcus aureus
Sulfur - pharmacology
Vancomycin Resistance
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Summary:One novel brominated nocardiopsistin D (1) and two new sulfur-containing nocardiopsistins E–F (2–3) were identified from Nocardiopsis sp. HB-J378. The biosynthetic gene cluster ncd featuring a brominase was identified. Compounds 1–3 exhibited significant anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activities with minimum inhibitory concentrations (MICs) of 0.098, 3.125, and 0.195 μg/mL, respectively. The single bromination in 1 drastically enhanced the anti-MRSA activity by 128-fold without altering cell toxicity and acquired new activities against the bacterial pathogens vancomycin-resistant S. aureus (VRSA), Enterococcus faecium, and Bacillus cereus.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c02879