Ester Formation via Nickel-Catalyzed Reductive Coupling of Alkyl Halides with Chloroformates

The synthesis of alkyl esters from readily available alkyl halides and chloroformates was achieved for the first time using a mild Ni-catalyzed reductive coupling protocol. Unactivated primary and secondary alkyl iodides as well as glycosyl, benzyl, and aminomethyl halides were successfully employed...

Full description

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 18; no. 23; pp. 6152 - 6155
Main Authors Zheng, Min, Xue, Weichao, Xue, Teng, Gong, Hegui
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 02.12.2016
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
IODIDES
CARBONYLATION
ACIDS
KETONE FORMATION
CO2
CHLORIDES
MECHANISMS
REDOX-ACTIVE ESTERS
ELECTROPHILES
BROMIDES
Online AccessGet full text

Cover

More Information
Summary:The synthesis of alkyl esters from readily available alkyl halides and chloroformates was achieved for the first time using a mild Ni-catalyzed reductive coupling protocol. Unactivated primary and secondary alkyl iodides as well as glycosyl, benzyl, and aminomethyl halides were successfully employed to yield products in moderate to excellent yields with high functional group tolerance.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b03158