Enantioselective Total Synthesis of CannabinoidsA Route for Analogue Development

A practical synthetic approach to Δ9-tetrahydrocannabinol (1) and cannabidiol (2) that provides scalable access to these natural products and should enable the generation of novel synthetic analogues is reported.

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Bibliographic Details
Published inOrganic letters Vol. 20; no. 2; pp. 381 - 384
Main Authors Shultz, Zachary P, Lawrence, Grant A, Jacobson, Jeffrey M, Cruz, Emmanuel J, Leahy, James W
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 19.01.2018
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
NAEGLERIA-FOWLERI
CLAISEN REARRANGEMENT
DELTA-9-TETRAHYDROCANNABINOL
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Summary:A practical synthetic approach to Δ9-tetrahydrocannabinol (1) and cannabidiol (2) that provides scalable access to these natural products and should enable the generation of novel synthetic analogues is reported.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b03668