Enantioselective Synthesis of Pyrazolo[3,4‑b]pyridone Derivatives with Antifungal Activities against Phytophthora capsici and Colletotrichum fructicola
A chiral NHC-catalyzed [3 + 3] cycloaddition reaction is developed for the efficient synthesis of pyrazolo[3,4-b]pyridones in generally excellent yields and optical purities. The R, S, and racemic forms of these molecules are systematically studied via in vitro tests that detect antifungal activit...
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Published in | Organic letters Vol. 25; no. 1; pp. 134 - 139 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society
13.01.2023
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Subjects | |
Online Access | Get full text |
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Summary: | A chiral NHC-catalyzed [3 + 3] cycloaddition reaction is developed for the efficient synthesis of pyrazolo[3,4-b]pyridones in generally excellent yields and optical purities. The R, S, and racemic forms of these molecules are systematically studied via in vitro tests that detect antifungal activity against Phytophthora capsici and Colletotrichum fructicola. Chiral compounds (R)-3i, (R)-3j, and (R)-3p are identified to have excellent inhibitory effects against P. capsici and C. fructicola. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/acs.orglett.2c03945 |