Synthesis of a Water-Soluble Carboxylatobiphen[4]arene and Its Selective Complexation toward Acetylcholine

The first water-soluble biphen[4]­arene containing eight carboxylato moieties (carboxylatobiphen[4]­arene, CBP4) has been synthesized. Selective molecular recognition of acetylcholine (ACh) against choline (Ch) and betaine (Bt) and pH-responsive host–guest complexation in aqueous media are described...

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Published inOrganic letters Vol. 18; no. 21; pp. 5740 - 5743
Main Authors Ma, Junwei, Meng, Qingbin, Hu, Xiaoshi, Li, Bin, Ma, Suxiang, Hu, Bingwen, Li, Jian, Jia, Xueshun, Li, Chunju
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 04.11.2016
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ORGANIC GUESTS
MOLECULAR RECOGNITION
SUPRAMOLECULAR POLYMERS
CONSTRUCTION
MACROCYCLE
CONTROLLED-RELEASE
SYSTEMS
TANDEM ENZYME ASSAYS
BINDING
HOST-GUEST COMPLEXATION
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Summary:The first water-soluble biphen[4]­arene containing eight carboxylato moieties (carboxylatobiphen[4]­arene, CBP4) has been synthesized. Selective molecular recognition of acetylcholine (ACh) against choline (Ch) and betaine (Bt) and pH-responsive host–guest complexation in aqueous media are described.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b03005