eFluorination Using Cheap and Readily Available Tetrafluoroborate Salts

A practical electrochemical method for the rapid, safer, and mild synthesis of tertiary hindered alkyl fluorides from carboxylic acids has been developed without the need for hydrofluoric acid salts or non-glass reactors. In this anodic fluorination, collidinium tetrafluoroborate acts as both the su...

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Published inOrganic letters Vol. 25; no. 9; pp. 1353 - 1358
Main Authors Leech, Matthew C., Nagornîi, Dmitrii, Walsh, Jamie M., Kiaku, Cyrille, Poole, Darren L., Mason, Joseph, Goodall, Iain C. A., Devo, Perry, Lam, Kevin
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 10.03.2023
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Summary:A practical electrochemical method for the rapid, safer, and mild synthesis of tertiary hindered alkyl fluorides from carboxylic acids has been developed without the need for hydrofluoric acid salts or non-glass reactors. In this anodic fluorination, collidinium tetrafluoroborate acts as both the supporting electrolyte and fluoride donor. A wide range of functional groups has been shown to be compatible, and the possibility of scale-up using flow electrochemistry has also been demonstrated.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c04305