Synthesis of Sulfilimines via Selective S–C Bond Formation in Water

Sulfilimines are valuable compounds both in organic synthesis and in pharmaceuticals. Here we developed a mild and simplified method for preparation of sulfilimines via selective S–C bond formation rather than traditional S–N bond formation. The method is both attractive and useful for the following...

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Published inOrganic letters Vol. 25; no. 12; pp. 2134 - 2138
Main Authors Chen, Yue, Fang, Dong-mei, Huang, He-sen, Nie, Xiao-kang, Zhang, Shi-qi, Cui, Xin, Tang, Zhuo, Li, Guang-xun
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 31.03.2023
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
VINYL
NITRENE TRANSFER
SULFOXIDES
SULFOXIMINES
SULFIDES
CATALYZED IMINATION
SULFIMIDES
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ATOM
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Summary:Sulfilimines are valuable compounds both in organic synthesis and in pharmaceuticals. Here we developed a mild and simplified method for preparation of sulfilimines via selective S–C bond formation rather than traditional S–N bond formation. The method is both attractive and useful for the following reasons: it uses a readily available alkylation reagent such alkyl bromide or alkyl iodide, it uses water as solvent, it is easy to perform, and it is convenient for late-stage diversification of drugs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c00604