Aberrant "Default Mode" Functional Connectivity in Schizophrenia

• Published in: The American journal of psychiatry Vol. 164; no. 3; pp. 450 - 457
• Main Authors: Garrity, Abigail G., Pearlson, Godfrey D., McKiernan, Kristen, Lloyd, Dan, Kiehl, Kent A., Calhoun, Vince D.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Association 01.03.2007
• Subjects: Acoustic Stimulation; Adult; Adult and adolescent clinical studies; Auditory Perception - physiology; Behavior; Biological and medical sciences; Brain; Brain - physiopathology; Brain Mapping; Cerebral Cortex - physiopathology; Discrimination (Psychology) - physiology; Female; Functional Laterality - physiology; Gyrus Cinguli - physiopathology; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging - statistics & numerical data; Male; Medical sciences; Middle Aged; Models, Neurological; Neural Pathways - physiopathology; NMR; Nuclear magnetic resonance; Parahippocampal Gyrus - physiology; Perceptual Masking - physiology; Principal Component Analysis; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - physiopathology; Schizophrenic Psychology; Severity of Illness Index; Psychosis; Schizophrenia

Objective: The "default mode" has been defined as a baseline condition of brain function and is of interest because its component brain regions are believed to be abnormal in schizophrenia. It was hypothesized that the default mode network would show abnormal activation and connectivity in...