Integrated Antimicrobial and Nonfouling Hydrogels to Inhibit the Growth of Planktonic Bacterial Cells and Keep the Surface Clean

• Published in: Langmuir Vol. 26; no. 13; pp. 10425 - 10428
• Main Authors: Cheng, Gang, Xue, Hong, Li, Guozhu, Jiang, Shaoyi
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 06.07.2010
• Subjects: Adsorption - drug effects; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Bacteria - drug effects; Betaine - chemistry; Chemistry; Colloidal gels. Colloidal sols; Colloidal state and disperse state; Escherichia coli K12 - drug effects; Exact sciences and technology; General and physical chemistry; Hydrogels - chemistry; Models, Theoretical; Plankton - drug effects; Proteins - chemistry; Salicylates - chemistry; Salicylates - pharmacology; Staphylococcus epidermidis - drug effects; Surface physical chemistry; Surface Properties; Colloidal gel; Hydrolysis; Ester; Adsorption; Growth; Device; Counter ion; Hydrogel; Potential; Release; Protein
• ISSN: 0743-7463; 1520-5827
• DOI: 10.1021/la101542m

A new strategy integrating antimicrobial and nonfouling/biocompatible properties is presented. A mild antimicrobial agent (salicylate) was incorporated into a carboxybetaine ester hydrogel, poly(N,N-dimethyl-N-(ethylcarbonylmethyl)-N-[2-(methacryloyloxy)-ethyl]ammonium salicylate) (pCBMA-1 C2 SA) hydrogel, as its anionic counterion. This new hydrogel provides a sustained release of antimicrobial agents to inhibit the growth of planktonic bacteria and create a nonfouling surface to prevent protein adsorption or bacterial accumulation upon the hydrolysis of carboxybetaine esters into zwitterionic groups. The pCBMA-1 C2 SA hydrogel inhibited the growth of both gram-negative Escherichia coli K12 and gram-positive Staphylococcus epidermidis by 99.9%. This hydrogel holds great potential in applications such as wound dressing and surface coatings for medical devices.