Direct One-Pot Reductive Amination of Aldehydes with Nitroarenes in a Domino Fashion: Catalysis by Gum-Acacia-Stabilized Palladium Nanoparticles

• Published in: Journal of organic chemistry Vol. 74; no. 22; pp. 8806 - 8809
• Main Authors: Sreedhar, B, Reddy, P. Surendra, Devi, D. Keerthi
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 20.11.2009; Amer Chemical Soc
• Subjects: Acacia - chemistry; Aldehydes - chemistry; Aliphatic compounds; Amination; Amines - chemical synthesis; Amines - chemistry; Catalysis; Chemistry; Chemistry, Organic; Exact sciences and technology; Metal Nanoparticles - chemistry; Nitrobenzenes - chemistry; Noncondensed benzenic compounds; Organic chemistry; Oxidation-Reduction; Palladium - chemistry; Physical Sciences; Preparations and properties; Science & Technology; Surface Properties; ORGANIC-SYNTHESIS; KETONES; HYDROGENATION; CYANOBOROHYDRIDE; CONSTRUCTION; MONOALKYLATION; CARBONYL-COMPOUNDS; N-ALKYLATION; SOLVENT; One pot reaction; Nitro compound; Aliphatic compound; Mild operating conditions; Hydrogen; Nanoparticle; Transition metal; Palladium; Gum arabic; Aldehyde; Chemical reduction; Carbonyl Compounds; Amination; Aromatic compound; Catalysis; Platinoid; Successive reaction
• ISSN: 0022-3263; 1520-6904
• DOI: 10.1021/jo901787t

This note describes the direct reductive amination of carbonyl compounds with nitroarenes using gum acacia-palladium nanoparticles, employing molecular hydrogen as the reductant. This methodology is found to be applicable to both aliphatic and aromatic aldehydes and a wide range of nitroarenes. The operational simplicity and the mild reaction conditions add to the value of this method as a practical alternative to the reductive amination of carbonyl compounds.