Rapid Synthesis of 1,3,5-Substituted 1,2,4-Triazoles from Carboxylic Acids, Amidines, and Hydrazines

A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines. This highly regioselective and one-pot process provides rapid access to highly diverse triazoles.

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Bibliographic Details
Published inJournal of organic chemistry Vol. 76; no. 4; pp. 1177 - 1179
Main Authors Castanedo, Georgette M, Seng, Pamela S, Blaquiere, Nicole, Trapp, Sean, Staben, Steven T
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.02.2011
Amer Chemical Soc
Subjects
Amidines - chemistry
Carboxylic Acids - chemistry
Catalysis
Chemistry
Chemistry, Organic
Combinatorial Chemistry Techniques
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Hydrazines - chemical synthesis
Hydrazines - chemistry
Molecular Structure
Organic chemistry
Physical Sciences
Preparations and properties
Science & Technology
Triazoles - chemical synthesis
One pot reaction
Amidine
Regioselectivity
Carboxylic acid
Nitrogen heterocycle
Triazole derivatives
Hydrazine
Chemical synthesis
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Summary:A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines. This highly regioselective and one-pot process provides rapid access to highly diverse triazoles.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/jo1023393