Mechanisms of Drug Release in Nanotherapeutic Delivery Systems

Wong and Choi examine mechanisms of drug release in nanotherapeutic delivery systems. They describe nanotherapeutics, nanocarriers, and biomarkers, along with their aims and scope. Their focus is then turned to the mechanisms of drug release via linker cleavage and the mechanisms of drug release via...

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Bibliographic Details
Published inChemical reviews Vol. 115; no. 9; pp. 3388 - 3432
Main Authors Wong, Pamela T, Choi, Seok Ki
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 13.05.2015
Subjects
Animals
Chemical reactions
Chemistry
Drug Carriers - chemistry
Drug delivery systems
Drug Liberation
Drug therapy
Humans
Nanotechnology
Theranostic Nanomedicine - methods
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Abstract Wong and Choi examine mechanisms of drug release in nanotherapeutic delivery systems. They describe nanotherapeutics, nanocarriers, and biomarkers, along with their aims and scope. Their focus is then turned to the mechanisms of drug release via linker cleavage and the mechanisms of drug release via control of carriers. A summary of their conclusions is presented, along with potential challenges in nanotherapeutic linker design.
AbstractList Wong and Choi examine mechanisms of drug release in nanotherapeutic delivery systems. They describe nanotherapeutics, nanocarriers, and biomarkers, along with their aims and scope. Their focus is then turned to the mechanisms of drug release via linker cleavage and the mechanisms of drug release via control of carriers. A summary of their conclusions is presented, along with potential challenges in nanotherapeutic linker design.
Author Wong, Pamela T
Choi, Seok Ki
AuthorAffiliation Michigan Nanotechnology Institute for Medicine and Biological Sciences, Department of Internal Medicine
University of Michigan
AuthorAffiliation_xml – name: Michigan Nanotechnology Institute for Medicine and Biological Sciences, Department of Internal Medicine
– name: University of Michigan
Author_xml – sequence: 1
  givenname: Pamela T
  surname: Wong
  fullname: Wong, Pamela T
– sequence: 2
  givenname: Seok Ki
  surname: Choi
  fullname: Choi, Seok Ki
  email: skchoi@umich.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25914945$$D View this record in MEDLINE/PubMed
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Snippet Wong and Choi examine mechanisms of drug release in nanotherapeutic delivery systems. They describe nanotherapeutics, nanocarriers, and biomarkers, along with...
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SubjectTerms Animals
Chemical reactions
Chemistry
Drug Carriers - chemistry
Drug delivery systems
Drug Liberation
Drug therapy
Humans
Nanotechnology
Theranostic Nanomedicine - methods
Title Mechanisms of Drug Release in Nanotherapeutic Delivery Systems
URI http://dx.doi.org/10.1021/cr5004634
https://www.ncbi.nlm.nih.gov/pubmed/25914945
https://www.proquest.com/docview/1706226281
https://www.proquest.com/docview/1680958671
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