Mechanisms of Drug Release in Nanotherapeutic Delivery Systems

Wong and Choi examine mechanisms of drug release in nanotherapeutic delivery systems. They describe nanotherapeutics, nanocarriers, and biomarkers, along with their aims and scope. Their focus is then turned to the mechanisms of drug release via linker cleavage and the mechanisms of drug release via...

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Bibliographic Details
Published inChemical reviews Vol. 115; no. 9; pp. 3388 - 3432
Main Authors Wong, Pamela T, Choi, Seok Ki
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 13.05.2015
Subjects
Animals
Chemical reactions
Chemistry
Drug Carriers - chemistry
Drug delivery systems
Drug Liberation
Drug therapy
Humans
Nanotechnology
Theranostic Nanomedicine - methods
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Summary:Wong and Choi examine mechanisms of drug release in nanotherapeutic delivery systems. They describe nanotherapeutics, nanocarriers, and biomarkers, along with their aims and scope. Their focus is then turned to the mechanisms of drug release via linker cleavage and the mechanisms of drug release via control of carriers. A summary of their conclusions is presented, along with potential challenges in nanotherapeutic linker design.
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ISSN:0009-2665
1520-6890
1520-6890
DOI:10.1021/cr5004634