Porous Stimuli-Responsive Self-Folding Electrospun Mats for 4D Biofabrication

We report fabrication and characterization of electrospun, porous multi-layer scaffolds based-on thermo-responsive polymers polycaprolactone (PCL) and poly­(N-isopropylacrylamide). We found that the electrospun mats fold into various 3D structures in an aqueous environment at different temperatures....

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Bibliographic Details
Published inBiomacromolecules Vol. 18; no. 10; pp. 3178 - 3184
Main Authors Apsite, Indra, Stoychev, Georgi, Zhang, Weizhong, Jehnichen, Dieter, Xie, Jin, Ionov, Leonid
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 09.10.2017
Subjects
3T3 Cells
Acrylamides - chemistry
Animals
Collagen - chemistry
Mice
Polyesters - chemistry
Porosity
Tissue Engineering - methods
Tissue Scaffolds - chemistry
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Summary:We report fabrication and characterization of electrospun, porous multi-layer scaffolds based-on thermo-responsive polymers polycaprolactone (PCL) and poly­(N-isopropylacrylamide). We found that the electrospun mats fold into various 3D structures in an aqueous environment at different temperatures. We could determine the mechanism behind different folding behaviors under different conditions by consideration of the properties of the individual polymers. At 37 °C in an aqueous environment, the scaffolds spontaneously rolled into tubular structures with PCL as the inner layer, making them suitable for cell encapsulation. We also demonstrated that the cell adhesion and viability could be improved by coating the polymers with collagen, showing the suitability of this scaffold for several tissue engineering applications.
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ISSN:1525-7797
1526-4602
DOI:10.1021/acs.biomac.7b00829