Diastereoselective Addition of 2H-2-Oxo-1,4,2-oxazaphosphinanes to Aldehydes and Imines

Diastereoselective additions of 2-hydrogeno-2-oxo-1,4,2-oxazaphosphinanes to aldehydes and imines are described. α,α‘-Diaminophosphinic and α-amino-α‘-hydroxyphosphinic derivatives were obtained with de's ranging from 24 to 90%.

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Bibliographic Details
Published inJournal of organic chemistry Vol. 70; no. 18; pp. 7035 - 7041
Main Authors Pirat, Jean-Luc, Monbrun, Jérôme, Virieux, David, Volle, Jean-Noël, Tillard, Monique, Cristau, Henri-Jean
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 02.09.2005
Amer Chemical Soc
Subjects
Aldehydes - chemical synthesis
Chemical Sciences
Chemistry
Chemistry, Organic
Exact sciences and technology
Heterocyclic compounds
Imines - chemical synthesis
Miscellaneous
Molecular Conformation
Organic chemistry
Phosphinic Acids - chemical synthesis
Physical Sciences
Preparations and properties
Science & Technology
ASYMMETRIC-SYNTHESIS
PHOSPHONATES
ENANTIOSELECTIVE SYNTHESIS
ANALOG
ACIDS
ALKYLATION
INHIBITORS
Oxazaphosphinane derivatives
Amine
Oxygen nitrogen phosphorus heterocycle
Organic phosphine
Imine
Aldehyde
Ketone
Diastereoselectivity
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Summary:Diastereoselective additions of 2-hydrogeno-2-oxo-1,4,2-oxazaphosphinanes to aldehydes and imines are described. α,α‘-Diaminophosphinic and α-amino-α‘-hydroxyphosphinic derivatives were obtained with de's ranging from 24 to 90%.
Bibliography:istex:F4F44A7269BB36F2A9B943EBC7D1FFBA012AE508
ark:/67375/TPS-4B2VKQ32-W
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-3263
1520-6904
DOI:10.1021/jo050201r