Using Ion–Molecule Reactions To Overcome Spectral Interferences in ICP-MS: A Guided Inquiry Approach for Upper-Level Undergraduate and Graduate Students

Almost all commercial quadrupole ICP-MS instruments use collision/reaction cells to either attenuate spectral interferences or shift the analyte of interest to an interference-free m/z (e.g., by O addition). A laboratory practical was developed to introduce the students to the basic operating princi...

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Bibliographic Details
Published inJournal of chemical education Vol. 95; no. 7; pp. 1211 - 1215
Main Author Newman, Karla
Format Journal Article
LanguageEnglish
Published Easton American Chemical Society and Division of Chemical Education, Inc 10.07.2018
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society
American Chemical Society
Subjects
Active Learning
Analytical chemistry
Charge transfer
Clustering
College Science
College students
Discovery Learning
Foreign Countries
Graduate students
Hands on Science
Inquiry
Interference
Laboratory Experiments
Laboratory Procedures
Learning transfer
Mass spectrometry
Molecular Structure
Organic chemistry
Physical chemistry
Quadrupoles
Research projects
Scientific Concepts
Scientific Methodology
Scientific Principles
Spectroscopy
Students
Teaching Methods
Vanadium
Canada
Hands-On Learning/Manipulatives
Atomic Spectroscopy
Graduate Education/Research
Instrumental Methods
Upper-Division Undergraduate
Analytical Chemistry
Physical Chemistry
Mass Spectrometry
Inquiry-Based/Discovery Learning
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Summary:Almost all commercial quadrupole ICP-MS instruments use collision/reaction cells to either attenuate spectral interferences or shift the analyte of interest to an interference-free m/z (e.g., by O addition). A laboratory practical was developed to introduce the students to the basic operating principles of ICP-MS using a hands-on approach, with an emphasis on practical strategies for the effective use of reaction cells in ICP-MS. Vanadium, and the ClO+ diatomic interference formed in HCl matrixes, was used as an illustrative example, which enabled students to explore charge transfer, clustering, condensation, and oxygen atom addition reactions of a single analyte, and evaluate the most effective approach for the chemical resolution of V+ and ClO+ ions. This laboratory practical provided graduate students with a basic skill set to support the effective use of ICP-MS with reaction cell technology in their research projects.
ISSN:0021-9584
1938-1328
DOI:10.1021/acs.jchemed.8b00026