Noninvasive Vagus Nerve Electrical Stimulation for Immune Modulation in Sepsis Therapy

Sepsis presents a significant medical challenge due to its intense inflammatory response to infection, often resulting in high mortality rates. A promising therapeutic strategy targets the cholinergic anti-inflammatory pathway (CAIP), which regulates immune responses. This study investigates the ing...

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Published inJournal of the American Chemical Society Vol. 147; no. 10; pp. 8406 - 8421
Main Authors Mac, Cam-Hoa, Nguyen, Giang Le Thi, Nguyen, Dien Thi My, Huang, Sheng-Min, Peng, Hsu-Hsia, Chang, Yen, Lo, Shih-Kai, Chiang, Hui-Hua Kenny, Yang, Yuan-Zhen, Song, Hsiang-Lin, Chia, Wei-Tso, Lin, Yu-Jung, Sung, Hsing-Wen
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 12.03.2025
Subjects
Animals
brain
death
Disease Models, Animal
electrical treatment
immunomodulation
inflammation
ingestion
Mice
Mice, Inbred C57BL
mortality
patients
Sepsis - immunology
Sepsis - therapy
spleen
stomach
therapeutics
transient receptor potential vanilloid channels
TRPV Cation Channels - metabolism
ultrasonics
Vagus Nerve
Vagus Nerve Stimulation - methods
weight loss
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Summary:Sepsis presents a significant medical challenge due to its intense inflammatory response to infection, often resulting in high mortality rates. A promising therapeutic strategy targets the cholinergic anti-inflammatory pathway (CAIP), which regulates immune responses. This study investigates the ingestion of piezoelectric particles that adhere to the stomach lining, specifically targeting TRPV1 receptors. In a mouse model of sepsis, these particles, when activated by low-intensity pulsed ultrasound, generate mild electrical pulses. These pulses stimulate vagal afferent fibers, transmitting signals to the brain and modulating the neural-immune network via the CAIP. Consequently, this leads to a reduction in systemic inflammation, mitigating weight loss, alleviating multiple tissue injuries, and preventing death by modulating immune cells in the spleen. This approach addresses the critical need for noninvasive sepsis therapies, potentially improving patient outcomes. Utilizing portable ultrasound equipment with minimal thermal effects, this technique offers a safe and convenient treatment option, even for home use.
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ISSN:0002-7863
1520-5126
1520-5126
DOI:10.1021/jacs.4c16367