Characterization of neurologic disease-associated Streptococcus suis strains within the United States swine herd and use of diagnostic tools

• Published in: Journal of clinical microbiology Vol. 62; no. 11; p. e0037424
• Main Authors: Santos Streauslin, Jessica, Nielsen, Daniel W., Schwartz, Kent J., Derscheid, Rachel J., Magstadt, Drew R., Burrough, Eric R., Gauger, Phillip C., Schumacher, Loni L., Rahe, Michael C., Michael, Alyona, Sitthicharoenchai, Panchan, Siepker, Christopher L., Matias Ferreyra, Franco, Nunes de Almeida, Marcelo, Main, Rodger, Bradner, Laura K., Hu, Xiao, Li, Ganwu, Poeta Silva, Ana Paula S., Sahin, Orhan, Arruda, Bailey L.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 13.11.2024
• Subjects: Animals; Bacteriology; Clinical Veterinary Microbiology; Serogroup; Streptococcal Infections - diagnosis; Streptococcal Infections - microbiology; Streptococcal Infections - veterinary; Streptococcus suis - classification; Streptococcus suis - genetics; Streptococcus suis - isolation & purification; Streptococcus suis - pathogenicity; Swine; Swine Diseases - diagnosis; Swine Diseases - microbiology; United States; Whole Genome Sequencing; United States; serotype distribution; central nervous system infections; characterization; diagnostic tools; virulence factors; Streptococcus suis
• ISSN: 0095-1137; 1098-660X; 1098-660X
• DOI: 10.1128/jcm.00374-24

Streptococcus suis is an important and complex systemic bacterial pathogen of swine. Characterization of S. suis strains originating from pigs with histologic confirmation of neurologic disease is limited. Review of swine diagnostic submissions revealed that fewer than half of cases from which S. suis was isolated from the brain had histologic evidence of neurologic disease. This finding demonstrates that clinical signs and site of isolation alone are not sufficient for identifying a neurologic disease-associated strain. Characterization of strains originating from cases with evidence of disease using classic and advanced diagnostic techniques revealed that neurologic disease-associated strains are diverse and commonly lack genes previously associated with virulence.