Intraocular penetration of rosoxacin in rabbits

Rosoxacin, a new synthetic antimicrobial agent, has a wide spectrum of activity that may prove beneficial in the treatment of ocular infections. To determine the penetration of rosoxacin into ocular tissues and serum of the rabbit after topical, subconjunctival, and intravenous (IV) administration,...

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Bibliographic Details
Published inArchives of ophthalmology (1960) Vol. 100; no. 4; p. 646
Main Authors Hulem, C D, Old, S E, Zeleznick, L D, Leopold, I H
Format Journal Article
LanguageEnglish
Published United States 01.04.1982
Subjects
4-Quinolones
Animals
Anti-Infective Agents - pharmacology
Choroid - analysis
Conjunctiva
Eye - analysis
Eye - drug effects
Female
Injections
Injections, Intravenous
Optic Nerve - analysis
Permeability
Quinolines - analysis
Quinolines - pharmacology
Quinolones
Rabbits
Retina - analysis
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Summary:Rosoxacin, a new synthetic antimicrobial agent, has a wide spectrum of activity that may prove beneficial in the treatment of ocular infections. To determine the penetration of rosoxacin into ocular tissues and serum of the rabbit after topical, subconjunctival, and intravenous (IV) administration, rosoxacin levels were measured using a microbiological assay after enzymatic digestion of the ocular tissues. Quantities of rosoxacin that should prove to be of therapeutic value were detectable in the anterior segment of the eye after topical or subconjunctival administration. Subconjunctival administration also resulted in high levels in the retina and choroid area and in the optic nerve. Low levels were detected in the retina and choroid 15 minutes following IV injection; however, no detectable levels were found in the ocular tissues after this period.
ISSN:0003-9950
DOI:10.1001/archopht.1982.01030030648025