The Flavonoid Glycoside from Abrus cantoniensis Hance Alleviates Alcoholic Liver Injury by Inhibiting Ferroptosis in an AMPK-Dependent Manner

• Published in: Journal of agricultural and food chemistry Vol. 72; no. 29; pp. 16323 - 16333
• Main Authors: Zhang, Yanqiu, Dong, Ruirui, Zhou, Huiling, Wang, Jingyi, Shi, Jianfei, Ye, Shengtao, Cheng, Yang, Leng, Yingrong, Xu, Wenjun, Kong, Lingyi, Zhang, Hao
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.07.2024
• Subjects: Bioactive Constituents, Metabolites, and Functions; ferroptosis; NRF2; Abrus cantoniensis Hance; alcoholic liver injury; oxidative stress
• ISSN: 0021-8561; 1520-5118; 1520-5118
• DOI: 10.1021/acs.jafc.4c02912

Abrus cantoniensis Hance is a vegetative food and can be used as a folk beverage or soup to clear liver toxins and prevent liver damage. However, the components and effects of A. cantoniensis Hance in alcohol-induced liver injury were unknown. This study aimed to obtain abundant phytochemicals from A. cantoniensis Hance and identify the potency of the isolates in preventing alcohol-induced liver injury. Alcohol-stimulated AML12 cells and Lieber–DeCarli diet-fed mice were used to establish in vitro and in vivo models, respectively. Our findings indicated that flavonoid glycosides, especially AH-15, could significantly alleviate alcohol-induced liver injury by inhibiting oxidative stress. Furthermore, we demonstrated that AH-15 inhibited ferroptosis induced by lipid peroxidation. Mechanically, we found that AH-15 regulated nuclear factor erythroid 2-related factor 2 (NRF2) expression via activation of AMP-activated protein kinase (AMPK) signaling. These results indicate that A. cantoniensis Hance is a great potential functional food for alleviating alcohol-induced liver injury.