Identification of New Compounds from Sage Flowers (Salvia officinalis L.) as Markers for Quality Control and the Influence of the Manufacturing Technology on the Chemical Composition and Antibacterial Activity of Sage Flower Extracts

Parts of Salvia species such as its flowers and leaves are currently used as a culinary herb and for some medicinal applications. To distinguish the different sage extracts it is necessary to analyze their individual chemical compositions. Their characteristic compounds might be established as marke...

Full description

Saved in:
Bibliographic Details
Published inJournal of agricultural and food chemistry Vol. 66; no. 8; pp. 1843 - 1853
Main Authors Gericke, Sebastian, Lübken, Tilo, Wolf, Diana, Kaiser, Martin, Hannig, Christian, Speer, Karl
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 28.02.2018
Amer Chemical Soc
Subjects
Agriculture
Agriculture, Multidisciplinary
Chemistry
Chemistry, Applied
Food Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Science & Technology
flowers
sage flower resin
caffeic acid ethyl ester
manufacturing technology
marker
salvia
salviquinone A
tri-p-coumaroylspermidine
salviquinone B
antibacterial activities
SPERMIDINE
GALDOSOL
IN-VITRO
POLYPHENOLS
ROSMARINUS-OFFICINALIS
ABIETANE DITERPENES
PHENOLIC DITERPENES
CONSTITUENTS
AMIDES
Online AccessGet full text

Cover

Abstract Parts of Salvia species such as its flowers and leaves are currently used as a culinary herb and for some medicinal applications. To distinguish the different sage extracts it is necessary to analyze their individual chemical compositions. Their characteristic compounds might be established as markers to differentiate between sage flowers and leaf extracts or to determine the manufacturing technology and storage conditions. Tri-p-coumaroylspermidine can be detected only in flowers and has been described here for Salvia and Lavandula species for the first time. Markers for oxidation processes are the novel compounds salviquinone A and B, which were generated from carnosol by exposure to oxygen. Caffeic acid ethyl ester was established as an indirect marker for the usage of ethanol as extraction solvent. The compounds were identified by LC-QTOF-HRESIMS, LC-MS, NMR, IR, and single-crystal X-ray diffraction after isolation by semipreparative HPLC. Furthermore, sage flower resin showed interesting antibacterial in vitro activities against Gram-positive and Gram-negative bacteria.
AbstractList Parts of Salvia species such as its flowers and leaves are currently used as a culinary herb and for some medicinal applications. To distinguish the different sage extracts it is necessary to analyze their individual chemical compositions. Their characteristic compounds might be established as markers to differentiate between sage flowers and leaf extracts or to determine the manufacturing technology and storage conditions. Tri-p-coumaroylspermidine can be detected only in flowers and has been described here for Salvia and Lavandula species for the first time. Markers for oxidation processes are the novel compounds salviquinone A and B, which were generated from carnosol by exposure to oxygen. Caffeic acid ethyl ester was established as an indirect marker for the usage of ethanol as extraction solvent. The compounds were identified by LC-QTOF-HRESIMS, LC-MS, NMR, IR, and single-crystal X-ray diffraction after isolation by semipreparative HPLC. Furthermore, sage flower resin showed interesting antibacterial in vitro activities against Gram-positive and Gram-negative bacteria.
Author Speer, Karl
Gericke, Sebastian
Hannig, Christian
Kaiser, Martin
Lübken, Tilo
Wolf, Diana
AuthorAffiliation Clinic of Operative and Pediatric Dentistry, Medical Faculty Carl Gustav Carus
Food Chemistry
Inorganic Chemistry
Institute of Microbiology
Technische UniCversität Dresden
TU Dresden
Organic Chemistry
AuthorAffiliation_xml – name: Technische UniCversität Dresden
– name: TU Dresden
– name:
– name: Food Chemistry
– name: Inorganic Chemistry
– name: Organic Chemistry
– name: Institute of Microbiology
– name: Clinic of Operative and Pediatric Dentistry, Medical Faculty Carl Gustav Carus
Author_xml – sequence: 1
  givenname: Sebastian
  orcidid: 0000-0002-9369-6187
  surname: Gericke
  fullname: Gericke, Sebastian
  email: sebastiangericke@gmx.net
– sequence: 2
  givenname: Tilo
  orcidid: 0000-0003-3383-9518
  surname: Lübken
  fullname: Lübken, Tilo
– sequence: 3
  givenname: Diana
  surname: Wolf
  fullname: Wolf, Diana
  organization: Technische UniCversität Dresden
– sequence: 4
  givenname: Martin
  surname: Kaiser
  fullname: Kaiser, Martin
– sequence: 5
  givenname: Christian
  surname: Hannig
  fullname: Hannig, Christian
  organization: TU Dresden
– sequence: 6
  givenname: Karl
  surname: Speer
  fullname: Speer, Karl
  email: karl.speer@chemie.tu-dresden.de
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29448760$$D View this record in MEDLINE/PubMed
BookMark eNqNkk9v0zAYxi00xLrBnRPycQhS7PxxkmMVbVCpA6GNc-Q4duvh2MV2VvqR-Ra8acvEBYmTLb-_5_EjP75AZ9ZZidBrSuaUpPQDF2H-wJWYVx0hRUWfoRktUpIUlFZnaEaASaqC0XN0EcIDIaQqSvICnad1nlclIzP0a9lLG7XSgkftLHYKf5Y73Lhh60bbB6y8G_AdX0t8Y9xO-oCv7rh51BxQUGnLjQ54NX-LecC33H-fEOU8_jrCJO7BykbvDOa2x3Ej8dIqM0or5HTXdHDL7ai4iKPXdo3vpdhYZ9x6jyHONG82coB45hgq6EPOyW0BwTsQSq9huhBRP04Xgu1fefH1z-gBCi_Rc8VNkK9O6yX6dnN933xKVl8-LpvFKuFZxmLCVcnqVFCSSSbqos9LrphidUezriCkZLIuGeddz0iVFkVfZ1RJQnugGOtrlV2iq6Pv1rsfowyxHXQQ0hhupRtDmxKSkTytCwYoOaLCuxC8VO3W64H7fUtJOxXcQsHtVHB7Khgkb07uYzfI_knwp1EAqiOwk51TQejpqZ8w-AJ5yhjNc9jRvNHxUHsDXUeQvvt_KdDvj_Qhoxs9_ITw7-C_Ab152J4
CitedBy_id crossref_primary_10_3390_foods12203737
crossref_primary_10_3390_ijms221910746
crossref_primary_10_1016_j_fbio_2022_102060
crossref_primary_10_3390_foods13121862
crossref_primary_10_1016_j_phytochem_2023_113686
crossref_primary_10_1016_j_anaerobe_2020_102194
crossref_primary_10_1016_j_celrep_2022_111236
crossref_primary_10_1016_j_indcrop_2019_111932
crossref_primary_10_3390_app11093898
crossref_primary_10_1055_a_1543_5502
crossref_primary_10_1021_acs_jafc_3c03281
crossref_primary_10_2174_1389201020666190722130440
crossref_primary_10_3390_molecules25051049
crossref_primary_10_1186_s43088_024_00498_6
crossref_primary_10_3390_foods11142132
crossref_primary_10_1021_acs_analchem_2c03329
crossref_primary_10_3390_nano12203629
crossref_primary_10_1016_j_jmrt_2021_02_063
crossref_primary_10_1016_j_jpba_2021_113951
crossref_primary_10_1002_smll_202306553
crossref_primary_10_1007_s00066_020_01684_y
crossref_primary_10_3390_ijms241310609
crossref_primary_10_3390_microorganisms10112172
crossref_primary_10_3390_antiox12081514
crossref_primary_10_3390_ijms24098038
Cites_doi 10.1186/s40064-016-2652-0
10.1016/j.jep.2010.07.054
10.12861/jrip.2013.18
10.1021/jf0715323
10.1021/jf703652a
10.1016/j.canlet.2011.02.005
10.1080/14786410500462843
10.1016/j.bmcl.2005.02.057
10.1002/jsfa.7745
10.2298/ABS0803421S
10.1016/S0141-8130(03)00075-8
10.1016/j.bmc.2013.02.019
10.1016/j.fitote.2009.05.015
10.1107/S2053229614024218
10.1111/j.1365-2672.2012.05380.x
10.1124/jpet.112.193847
10.1016/0031-9422(92)80282-J
10.1016/S0031-9422(01)00415-0
10.1107/S0108767307043930
10.1016/0031-9422(95)00151-V
10.1055/s-2003-37712
10.1016/S0031-9422(00)88735-X
10.1007/BF01943861
10.1111/j.1574-6968.2001.tb10765.x
10.1002/1521-3773(20020104)41:1<48::AID-ANIE48>3.0.CO;2-U
10.1007/BF01201765
10.1016/0003-9861(84)90201-7
10.1021/jf001102b
10.1016/S0308-8146(01)00198-4
10.1016/S0304-3835(99)00160-3
10.1016/S0031-9422(00)90834-3
10.1016/S0031-9422(00)94798-8
10.1248/cpb.49.915
10.1007/BF01161344
10.1016/S0031-9422(00)85496-5
ContentType Journal Article
Copyright Copyright © 2018 American Chemical Society
Copyright_xml – notice: Copyright © 2018 American Chemical Society
DBID 1KM
BLEPL
DTL
HBEAY
NPM
AAYXX
CITATION
7X8
DOI 10.1021/acs.jafc.8b00581
DatabaseName Index Chemicus
Web of Science Core Collection
Science Citation Index Expanded
Web of Science - Science Citation Index Expanded - 2018
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle Web of Science
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
Web of Science
PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 1KM
  name: Index Chemicus
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC
  sourceTypes:
    Enrichment Source
    Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Agriculture
Chemistry
EISSN 1520-5118
EndPage 1853
ExternalDocumentID 10_1021_acs_jafc_8b00581
29448760
000426614400014
b682908529
Genre Journal Article
GroupedDBID -
55A
5GY
5VS
7~N
85S
AABXI
ABFLS
ABMVS
ABUCX
ACGFS
ACJ
ACS
AEESW
AENEX
AFEFF
ALMA_UNASSIGNED_HOLDINGS
AQSVZ
CS3
DU5
EBS
ED
ED~
EJD
F5P
GNL
GX1
IH9
JG
JG~
LG6
P2P
ROL
TWZ
UI2
VF5
VG9
W1F
WH7
X
---
-~X
.K2
1KM
4.4
AAHBH
ABJNI
ABQRX
ACGFO
ADHLV
AGXLV
AHGAQ
BAANH
BLEPL
CUPRZ
DTL
GGK
GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED
NPM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-a336t-af7692c103e6c95d47af6f69b13b50076e976aabd608255d931fe01daf666d9f3
IEDL.DBID ACS
ISICitedReferencesCount 29
ISICitedReferencesURI https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=000426614400014
ISSN 0021-8561
IngestDate Sat Aug 17 03:00:30 EDT 2024
Fri Aug 23 02:42:54 EDT 2024
Wed Oct 16 01:00:58 EDT 2024
Tue Sep 17 22:47:04 EDT 2024
Fri Nov 08 20:04:59 EST 2024
Thu Feb 04 21:42:53 EST 2021
IsPeerReviewed true
IsScholarly true
Issue 8
Keywords flowers
sage flower resin
caffeic acid ethyl ester
manufacturing technology
marker
salvia
salviquinone A
tri-p-coumaroylspermidine
salviquinone B
antibacterial activities
SPERMIDINE
GALDOSOL
IN-VITRO
POLYPHENOLS
ROSMARINUS-OFFICINALIS
ABIETANE DITERPENES
PHENOLIC DITERPENES
CONSTITUENTS
AMIDES
Language English
LinkModel DirectLink
LogoURL https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg
MergedId FETCHMERGED-LOGICAL-a336t-af7692c103e6c95d47af6f69b13b50076e976aabd608255d931fe01daf666d9f3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-3383-9518
0000-0002-9369-6187
0000-0001-5954-7172
PMID 29448760
PQID 2003042956
PQPubID 23479
PageCount 11
ParticipantIDs webofscience_primary_000426614400014
acs_journals_10_1021_acs_jafc_8b00581
crossref_primary_10_1021_acs_jafc_8b00581
pubmed_primary_29448760
webofscience_primary_000426614400014CitationCount
proquest_miscellaneous_2003042956
ProviderPackageCode JG~
55A
AABXI
GNL
VF5
7~N
ACJ
VG9
W1F
ACS
AEESW
AFEFF
ABMVS
ABUCX
IH9
AQSVZ
ED~
UI2
PublicationCentury 2000
PublicationDate 20180228
2018-02-28
2018-Feb-28
PublicationDateYYYYMMDD 2018-02-28
PublicationDate_xml – month: 02
  year: 2018
  text: 20180228
  day: 28
PublicationDecade 2010
PublicationPlace WASHINGTON
PublicationPlace_xml – name: WASHINGTON
– name: United States
PublicationTitle Journal of agricultural and food chemistry
PublicationTitleAbbrev J AGR FOOD CHEM
PublicationTitleAlternate J. Agric. Food Chem
PublicationYear 2018
Publisher American Chemical Society
Amer Chemical Soc
Publisher_xml – name: American Chemical Society
– name: Amer Chemical Soc
References Aydogmus, Z (WOS:000238074900013) 2006; 20
GONZALEZ, AG (WOS:A1992HM38900043) 1992; 31
DJARMATI, Z (WOS:A1992JU24200012) 1992; 22
GONZALEZ, AG (WOS:A1973R930100003) 1973; 29
Behradmanesh, S (WOS:000446261200008) 2013; 2
Bauer, J (WOS:000305395400018) 2012; 342
Kanetis, L (WOS:000390708500009) 2017; 97
MARTINTANGUY, J (WOS:A1978FX78300017) 1978; 17
Ito, H (WOS:000081732100002) 1999; 143
Sheldrick, G. M. (000426614400014.36) 2014
MOUJIR, L (WOS:A1993MN64800007) 1993; 34
SCHWARZ, K (WOS:A1992JG21900001) 1992; 195
Sheldrick, M. (000426614400014.37) 2014
Smidling, D (WOS:000258524700010) 2008; 60
Lu, YR (WOS:000173714800001) 2002; 59
Walters, D (WOS:000170159300022) 2001; 201
Bozin, B (WOS:000249455100038) 2007; 55
Christensen, KB (WOS:000284442100014) 2010; 132
Kintzios, S. E. (000426614400014.23) 2000; 14
Steiner, T (WOS:000173124900007) 2002; 41
Ma, C (WOS:000169577600022) 2001; 49
TADA, M (WOS:A1994MU93100051) 1994; 35
British Herbal Medicine Association (000426614400014.3) 2012
Johnson, JJ (WOS:000290133600001) 2011; 305
Fischedick, JT (WOS:000317403200019) 2013; 21
Sobolev, VS (WOS:000255655600015) 2008; 56
MEURER, B (WOS:A1986AZF9800029) 1986; 25
Walther, H. J. (000426614400014.46) 1956
(000426614400014.1) 2014
Mayer, B (WOS:000270077000009) 2009; 80
Lu, YR (WOS:000171511900009) 2001; 75
Oelschlaegel, S. (000426614400014.32) 2012; 2
Masterova, E. (000426614400014.28) 1996; 45
(000426614400014.2) 2000
Brand, N. (000426614400014.9) 2007; 14
Kavvadias, D (WOS:000181794800003) 2003; 69
Son, KH (WOS:000228432900012) 2005; 15
Oppermann, Y. (000426614400014.33) 2013
Smullen, J (WOS:000308644600024) 2012; 113
Hill, J. (000426614400014.17) 1778
Eghtesadi, F (WOS:000381633300002) 2016; 5
Capek, P (WOS:000186835800017) 2003; 33
Sheldrick, GM (WOS:000347804100002) 2015; 71
SLOCUM, RD (WOS:A1984TX06400001) 1984; 235
Kandil, M. M. (000426614400014.20) 2015; 8
Santos-Gomes, PC (WOS:000169536500035) 2001; 49
Zerm, H. (000426614400014.48) 2000
BOKERN, M (WOS:A1995RN85800016) 1995; 39
ref45/cit45
ref27/cit27
ref23/cit23
ref8/cit8
ref2/cit2
ref34/cit34
ref37/cit37
Masterova E. (ref16/cit16) 1996; 45
ref20/cit20
ref48/cit48
ref17/cit17
ref10/cit10
ref35/cit35
ref19/cit19
ref42/cit42
ref49/cit49
ref13/cit13
Behradmanesh S. (ref9/cit9) 2013; 2
ref24/cit24
ref38/cit38
ref6/cit6
ref36/cit36
ref18/cit18
Brand N. (ref1/cit1) 2007; 14
ref11/cit11
ref25/cit25
ref29/cit29
ref32/cit32
ref39/cit39
Kandil M. M. (ref46/cit46) 2015; 8
ref14/cit14
ref5/cit5
ref43/cit43
ref28/cit28
ref40/cit40
Oelschlaegel S. (ref31/cit31) 2012; 2
ref26/cit26
Kintzios S. E. (ref3/cit3) 2000; 14
ref12/cit12
ref15/cit15
Hill J. (ref21/cit21) 1778
ref41/cit41
ref22/cit22
ref33/cit33
ref4/cit4
ref30/cit30
ref47/cit47
ref44/cit44
ref7/cit7
References_xml – volume: 69
  start-page: 113
  year: 2003
  ident: WOS:000181794800003
  article-title: Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor
  publication-title: PLANTA MEDICA
  contributor:
    fullname: Kavvadias, D
– volume: 5
  start-page: ARTN 1068
  year: 2016
  ident: WOS:000381633300002
  article-title: Abietane and nor-abitane diterpenoids from the roots of Salvia rhytidea
  publication-title: SPRINGERPLUS
  doi: 10.1186/s40064-016-2652-0
  contributor:
    fullname: Eghtesadi, F
– volume: 132
  start-page: 127
  year: 2010
  ident: WOS:000284442100014
  article-title: Activation of the nuclear receptor PPAR gamma by metabolites isolated from sage (Salvia officinalis L.)
  publication-title: JOURNAL OF ETHNOPHARMACOLOGY
  doi: 10.1016/j.jep.2010.07.054
  contributor:
    fullname: Christensen, KB
– year: 2014
  ident: 000426614400014.1
  publication-title: European Pharmacopoeia 8.0
– volume: 45
  start-page: 242
  year: 1996
  ident: 000426614400014.28
  article-title: Royleanone in der Wurzel der einheimischen Salvia officinalis L. und ihre antimikrobielle Aktivitat
  publication-title: Tschech. und Slowak. Pharmazie
  contributor:
    fullname: Masterova, E.
– volume: 59
  start-page: 117
  year: 2002
  ident: WOS:000173714800001
  article-title: Polyphenolics of Salvia - a review
  publication-title: PHYTOCHEMISTRY
  contributor:
    fullname: Lu, YR
– volume: 14
  year: 2000
  ident: 000426614400014.23
  article-title: The genus Salvia
  publication-title: Medicinal and aromatic plants-industrial profiles
  contributor:
    fullname: Kintzios, S. E.
– volume: 34
  start-page: 1493
  year: 1993
  ident: WOS:A1993MN64800007
  article-title: STRUCTURE-ANTIMICROBIAL ACTIVITY RELATIONSHIPS OF ABIETANE DITERPENES FROM SALVIA SPECIES
  publication-title: PHYTOCHEMISTRY
  contributor:
    fullname: MOUJIR, L
– year: 2012
  ident: 000426614400014.3
  publication-title: Sage leaf. Salviae officinalis folium
  contributor:
    fullname: British Herbal Medicine Association
– volume: 17
  start-page: 1927
  year: 1978
  ident: WOS:A1978FX78300017
  article-title: DISTRIBUTION OF HYDROXYCINNAMIC ACID-AMIDES IN FLOWERING PLANTS
  publication-title: PHYTOCHEMISTRY
  contributor:
    fullname: MARTINTANGUY, J
– volume: 2
  start-page: 51
  year: 2013
  ident: WOS:000446261200008
  article-title: Effect of Salvia officinalis on diabetic patients
  publication-title: JOURNAL OF RENAL INJURY PREVENTION
  doi: 10.12861/jrip.2013.18
  contributor:
    fullname: Behradmanesh, S
– year: 2014
  ident: 000426614400014.37
  publication-title: SADABS Area Detector Absorption Correction, version 2014/5
  contributor:
    fullname: Sheldrick, M.
– volume: 25
  start-page: 433
  year: 1986
  ident: WOS:A1986AZF9800029
  article-title: HYDROXYCINNAMIC ACID SPERMIDINE AMIDES FROM POLLEN OF CORYLUS-AVELLANA L
  publication-title: PHYTOCHEMISTRY
  contributor:
    fullname: MEURER, B
– year: 2000
  ident: 000426614400014.48
  publication-title: Antioxidative Eigenschaften verschiedener Extrakte aus Salvia officinalis L
  contributor:
    fullname: Zerm, H.
– volume: 29
  start-page: 1471
  year: 1973
  ident: WOS:A1973R930100003
  article-title: CONSTITUENTS OF LABIATAE .19. STRUCTURE OF GALDOSOL, A NEW DITERPENE FROM SALVIA-CANARIENSIS-L
  publication-title: EXPERIENTIA
  contributor:
    fullname: GONZALEZ, AG
– volume: 2
  start-page: 427
  year: 2012
  ident: 000426614400014.32
  article-title: The essential oil content and composition of selected Salvia species, sage teas, and sage drops in food chemistry
  publication-title: J. Food Sci. Eng.
  contributor:
    fullname: Oelschlaegel, S.
– year: 1956
  ident: 000426614400014.46
  publication-title: Chemische und bakteriologische Untersuchungen des Harzkorpers von Salvia officinalis L
  contributor:
    fullname: Walther, H. J.
– volume: 14
  start-page: 124
  year: 2007
  ident: 000426614400014.9
  article-title: Salvia
  publication-title: Hagers Enzyklopiidie der Arzneipflanzen and Drogen
  contributor:
    fullname: Brand, N.
– volume: 55
  start-page: 7879
  year: 2007
  ident: WOS:000249455100038
  article-title: Antimicrobial and antioxidant properties of rosemary and sage (Rosmarinus officinalis L. and Salvia officinalis L., lamiaceae) essential oils
  publication-title: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
  doi: 10.1021/jf0715323
  contributor:
    fullname: Bozin, B
– volume: 56
  start-page: 2960
  year: 2008
  ident: WOS:000255655600015
  article-title: Spermidine and flavonoid conjugates from peanut (Arachis hypogaea) flowers
  publication-title: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
  doi: 10.1021/jf703652a
  contributor:
    fullname: Sobolev, VS
– volume: 305
  start-page: 1
  year: 2011
  ident: WOS:000290133600001
  article-title: Carnosol: A promising anti-cancer and anti-inflammatory agent
  publication-title: CANCER LETTERS
  doi: 10.1016/j.canlet.2011.02.005
  contributor:
    fullname: Johnson, JJ
– volume: 235
  start-page: 283
  year: 1984
  ident: WOS:A1984TX06400001
  article-title: THE PHYSIOLOGY AND BIOCHEMISTRY OF POLYAMINES IN PLANTS
  publication-title: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
  contributor:
    fullname: SLOCUM, RD
– volume: 20
  start-page: 775
  year: 2006
  ident: WOS:000238074900013
  article-title: Constituents of Salvia microphylla
  publication-title: NATURAL PRODUCT RESEARCH
  doi: 10.1080/14786410500462843
  contributor:
    fullname: Aydogmus, Z
– volume: 15
  start-page: 2019
  year: 2005
  ident: WOS:000228432900012
  article-title: Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  doi: 10.1016/j.bmcl.2005.02.057
  contributor:
    fullname: Son, KH
– volume: 97
  start-page: 452
  year: 2017
  ident: WOS:000390708500009
  article-title: Edible coating composed of chitosan and Salvia fruticosa Mill. extract for the control of grey mould of table grapes
  publication-title: JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
  doi: 10.1002/jsfa.7745
  contributor:
    fullname: Kanetis, L
– year: 2014
  ident: 000426614400014.36
  publication-title: SHELX2014, Programs for Crystal Structure Determination
  contributor:
    fullname: Sheldrick, G. M.
– volume: 39
  start-page: 1371
  year: 1995
  ident: WOS:A1995RN85800016
  article-title: TRISUBSTITUTED HYDROXYCINNAMIC ACID SPERMIDINES FROM QUERCUS-DENTATA POLLEN
  publication-title: PHYTOCHEMISTRY
  contributor:
    fullname: BOKERN, M
– volume: 75
  start-page: 197
  year: 2001
  ident: WOS:000171511900009
  article-title: Antioxidant activities of polyphenols from sage (Salvia officinalis)
  publication-title: FOOD CHEMISTRY
  contributor:
    fullname: Lu, YR
– volume: 41
  start-page: 48
  year: 2002
  ident: WOS:000173124900007
  article-title: The hydrogen bond in the solid state
  publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
  contributor:
    fullname: Steiner, T
– volume: 60
  start-page: 421
  year: 2008
  ident: WOS:000258524700010
  article-title: Evaluation of antiviral activity of fractionated extracts of sage Salvia officinalis L. (Lamiaceae)
  publication-title: ARCHIVES OF BIOLOGICAL SCIENCES
  doi: 10.2298/ABS0803421S
  contributor:
    fullname: Smidling, D
– volume: 195
  start-page: 95
  year: 1992
  ident: WOS:A1992JG21900001
  article-title: ANTIOXIDATIVE CONSTITUENTS OF ROSMARINUS-OFFICINALIS AND SALVIA-OFFICINALIS .1. DETERMINATION OF PHENOLIC DITERPENES WITH ANTIOXIDATIVE ACTIVITY AMONGST TOCOCHROMANOLS USING HPLC
  publication-title: ZEITSCHRIFT FUR LEBENSMITTEL-UNTERSUCHUNG UND-FORSCHUNG
  contributor:
    fullname: SCHWARZ, K
– volume: 201
  start-page: 255
  year: 2001
  ident: WOS:000170159300022
  article-title: Antifungal activity of three spermidine conjugates
  publication-title: FEMS MICROBIOLOGY LETTERS
  contributor:
    fullname: Walters, D
– volume: 49
  start-page: 915
  year: 2001
  ident: WOS:000169577600022
  article-title: Inhibitory effects on HIV-1 protease of tri-p-coumaroylspermidine from Artemisia caruifolia and related amides
  publication-title: CHEMICAL & PHARMACEUTICAL BULLETIN
  contributor:
    fullname: Ma, C
– volume: 143
  start-page: 5
  year: 1999
  ident: WOS:000081732100002
  article-title: Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima
  publication-title: CANCER LETTERS
  contributor:
    fullname: Ito, H
– volume: 49
  start-page: 2908
  year: 2001
  ident: WOS:000169536500035
  article-title: Organ- and season-dependent variation in the essential oil composition of Salvia officinalis L. cultivated at two different sites
  publication-title: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
  contributor:
    fullname: Santos-Gomes, PC
– volume: 33
  start-page: 113
  year: 2003
  ident: WOS:000186835800017
  article-title: Characterization of immunomodulatory polysaccharides from Salvia officinalis L.
  publication-title: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
  doi: 10.1016/S0141-8130(03)00075-8
  contributor:
    fullname: Capek, P
– year: 2000
  ident: 000426614400014.2
  article-title: Use of extracts from sage for producing a deodorizing preparation
  publication-title: U. S. Patent
– volume: 31
  start-page: 1297
  year: 1992
  ident: WOS:A1992HM38900043
  article-title: DITERPENES FROM SALVIA-MELLIFERA AND THEIR BIOGENETIC SIGNIFICANCE
  publication-title: PHYTOCHEMISTRY
  contributor:
    fullname: GONZALEZ, AG
– volume: 22
  start-page: 585
  year: 1992
  ident: WOS:A1992JU24200012
  article-title: NMR-STUDIES AND X-RAY CRYSTALLOGRAPHY OF GALDOSOL 5-METHYL ETHER FROM SALVIA-OFFICINALIS L
  publication-title: JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH
  contributor:
    fullname: DJARMATI, Z
– volume: 21
  start-page: 2618
  year: 2013
  ident: WOS:000317403200019
  article-title: Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway
  publication-title: BIOORGANIC & MEDICINAL CHEMISTRY
  doi: 10.1016/j.bmc.2013.02.019
  contributor:
    fullname: Fischedick, JT
– volume: 8
  start-page: 174
  year: 2015
  ident: 000426614400014.20
  article-title: Effect of putrescine and uniconazole on some flowering characteristics, and some chemical constituents of Salvias splendens F. plant
  publication-title: Int. J. ChemTech Res.
  contributor:
    fullname: Kandil, M. M.
– volume: 35
  start-page: 539
  year: 1994
  ident: WOS:A1994MU93100051
  article-title: ANTIVIRAL DITERPENES FROM SALVIA-OFFICINALIS
  publication-title: PHYTOCHEMISTRY
  contributor:
    fullname: TADA, M
– volume: 80
  start-page: 421
  year: 2009
  ident: WOS:000270077000009
  article-title: Gastroprotective constituents of Salvia officinalis L.
  publication-title: FITOTERAPIA
  doi: 10.1016/j.fitote.2009.05.015
  contributor:
    fullname: Mayer, B
– volume: 71
  start-page: 3
  year: 2015
  ident: WOS:000347804100002
  article-title: Crystal structure refinement with SHELXL
  publication-title: ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY
  doi: 10.1107/S2053229614024218
  contributor:
    fullname: Sheldrick, GM
– year: 2013
  ident: 000426614400014.33
  publication-title: Regulation des Methioninzyklus durch die Polyaminbiosynthese und den Ethylensignalweg in Arabidopsis thaliana
  contributor:
    fullname: Oppermann, Y.
– year: 1778
  ident: 000426614400014.17
  publication-title: Das heilige Kraut, oder die Krafte der Salbei zur Verlangerung des menschlichen Lebens
  contributor:
    fullname: Hill, J.
– volume: 113
  start-page: 964
  year: 2012
  ident: WOS:000308644600024
  article-title: Prevention of artificial dental plaque formation in vitro by plant extracts
  publication-title: JOURNAL OF APPLIED MICROBIOLOGY
  doi: 10.1111/j.1365-2672.2012.05380.x
  contributor:
    fullname: Smullen, J
– volume: 342
  start-page: 169
  year: 2012
  ident: WOS:000305395400018
  article-title: Carnosol and Carnosic Acids from Salvia officinalis Inhibit Microsomal Prostaglandin E-2 Synthase-1
  publication-title: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
  doi: 10.1124/jpet.112.193847
  contributor:
    fullname: Bauer, J
– ident: ref48/cit48
  doi: 10.1111/j.1365-2672.2012.05380.x
– ident: ref49/cit49
  doi: 10.1016/0031-9422(92)80282-J
– ident: ref25/cit25
– ident: ref39/cit39
  doi: 10.1021/jf703652a
– ident: ref18/cit18
  doi: 10.1016/j.fitote.2009.05.015
– ident: ref2/cit2
  doi: 10.1016/S0031-9422(01)00415-0
– ident: ref47/cit47
– ident: ref28/cit28
  doi: 10.1107/S0108767307043930
– volume: 8
  start-page: 174
  year: 2015
  ident: ref46/cit46
  publication-title: Int. J. ChemTech Res.
  contributor:
    fullname: Kandil M. M.
– volume: 2
  start-page: 51
  year: 2013
  ident: ref9/cit9
  publication-title: J. Renal Inj. Prev.
  contributor:
    fullname: Behradmanesh S.
– ident: ref22/cit22
– ident: ref32/cit32
  doi: 10.1016/0031-9422(95)00151-V
– ident: ref8/cit8
  doi: 10.1016/j.canlet.2011.02.005
– ident: ref20/cit20
  doi: 10.1016/S0141-8130(03)00075-8
– ident: ref23/cit23
– ident: ref15/cit15
  doi: 10.1002/jsfa.7745
– volume: 2
  start-page: 427
  year: 2012
  ident: ref31/cit31
  publication-title: J. Food Sci. Eng.
  contributor:
    fullname: Oelschlaegel S.
– ident: ref29/cit29
– ident: ref36/cit36
  doi: 10.1080/14786410500462843
– ident: ref27/cit27
– ident: ref11/cit11
  doi: 10.1055/s-2003-37712
– ident: ref42/cit42
  doi: 10.1016/S0031-9422(00)88735-X
– volume: 14
  volume-title: Medicinal and aromatic plants - industrial profiles
  year: 2000
  ident: ref3/cit3
  contributor:
    fullname: Kintzios S. E.
– ident: ref33/cit33
  doi: 10.1007/BF01943861
– ident: ref40/cit40
  doi: 10.1111/j.1574-6968.2001.tb10765.x
– ident: ref41/cit41
  doi: 10.1002/1521-3773(20020104)41:1<48::AID-ANIE48>3.0.CO;2-U
– ident: ref5/cit5
  doi: 10.1007/BF01201765
– volume-title: Das heilige Kraut, oder die Kräfte der Salbei zur Verlängerung des menschlichen Lebens
  year: 1778
  ident: ref21/cit21
  contributor:
    fullname: Hill J.
– ident: ref26/cit26
– ident: ref6/cit6
  doi: 10.1124/jpet.112.193847
– ident: ref44/cit44
  doi: 10.1016/0003-9861(84)90201-7
– ident: ref19/cit19
  doi: 10.1016/j.bmc.2013.02.019
– ident: ref24/cit24
– ident: ref30/cit30
  doi: 10.1021/jf001102b
– ident: ref4/cit4
  doi: 10.1016/S0308-8146(01)00198-4
– ident: ref45/cit45
– ident: ref7/cit7
  doi: 10.1016/S0304-3835(99)00160-3
– ident: ref17/cit17
  doi: 10.1016/S0031-9422(00)90834-3
– ident: ref37/cit37
  doi: 10.1186/s40064-016-2652-0
– ident: ref12/cit12
  doi: 10.2298/ABS0803421S
– volume: 45
  start-page: 242
  year: 1996
  ident: ref16/cit16
  publication-title: Tschech. und Slowak. Pharmazie
  contributor:
    fullname: Masterova E.
– ident: ref13/cit13
  doi: 10.1016/S0031-9422(00)94798-8
– ident: ref38/cit38
  doi: 10.1248/cpb.49.915
– volume: 14
  start-page: 124
  volume-title: Hagers Enzyklopädie der Arzneipflanzen und Drogen
  year: 2007
  ident: ref1/cit1
  contributor:
    fullname: Brand N.
– ident: ref34/cit34
  doi: 10.1007/BF01161344
– ident: ref14/cit14
  doi: 10.1021/jf0715323
– ident: ref43/cit43
  doi: 10.1016/S0031-9422(00)85496-5
– ident: ref35/cit35
  doi: 10.1016/j.bmcl.2005.02.057
– ident: ref10/cit10
  doi: 10.1016/j.jep.2010.07.054
SSID ssj0008570
Score 2.4412792
Snippet Parts of Salvia species such as its flowers and leaves are currently used as a culinary herb and for some medicinal applications. To distinguish the different...
Source Web of Science
SourceID proquest
crossref
pubmed
webofscience
acs
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1843
SubjectTerms Agriculture
Agriculture, Multidisciplinary
Chemistry
Chemistry, Applied
Food Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Science & Technology
Title Identification of New Compounds from Sage Flowers (Salvia officinalis L.) as Markers for Quality Control and the Influence of the Manufacturing Technology on the Chemical Composition and Antibacterial Activity of Sage Flower Extracts
URI http://dx.doi.org/10.1021/acs.jafc.8b00581
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000426614400014
https://www.ncbi.nlm.nih.gov/pubmed/29448760
https://search.proquest.com/docview/2003042956
Volume 66
WOS 000426614400014
WOSCitedRecordID wos000426614400014
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZQucAByju0RYNUJHpIiB9xNsfVqquCKJdSqbfIjxgBVRbVWQT8Y_4FHju7LbRCe42tiS2P7W88M98Qss_khGvJgnViLc-FY02uLXc5FVYL23HjLD7oH3-QR6fi3Vl1dkmT868Hn9E3yvjii3KmmKDGYJb1bVaHvYEwaHayPnWRqD2Fc9B8EkDB6JK8SQJeRMb_fRFdQ5c3XkTx0pnfT9WLfOQqxFiTr8Vy0IX5dZ3JcYP5bJN7I_aEaVKWB-RW1z8kd6efLkb-je4R-Z0Sd934kgcLB-EYBDw1sP6SB0xHAQz0gfl5LLAGr0_U-ffPChIZBeJ6D--LA1AeMBEIuwRgDIms4yfMUmw8qN5CAJ_wdlUlBf-FH45Vv8R0i5g_CZdP_xCGg-0rioM0qBRyFqVNw8B1Ip_GWZpUFwPFXhkvHP4YMDHMPyan88OPs6N8rAaRK87lkCtXy4YZWvJOmqayolZOOtloynWFDsUuICultJVo9Va24dR1JbWhl5S2cfwJ2eoXffeMgBDMaNqgNjrhtFal0sLJSumK17ZWGXkVVqkdd7Nvo6Oe0TZ-DEvXjkuXkYOVCrXfEjnIf_q-XOlYG3YwumVU3y2WHguB4ptSMFQz8jQp31oaa4L5XMsyI_tXtXHdXkYbGI36aOxmhG7SbTbSvyPtwfB8w8nukDsBLE5SOv8u2Roult1eAGSDfhF34h_onTQU
link.rule.ids 315,783,787,2772,27088,27936,27937,57066,57116
linkProvider American Chemical Society
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELaq9gAcKO-G5yAViR6yxHHibI6rVVdb2O2BtlJvkR3HVR_KoiaLgH_Mv2DGTrYFKlSujjUZy2PPjGfmG8a2YzkUWsbonRgjwsTGeaiNsCFPjE5MJUpr6EF_vi-nR8nH4_R4jfG-FgaZaJBS44L4V-gC_AONnSlbDoYkOFRsvZFmqC_JGhofrC5fwmv3WR08HKJt0EUmb6JA-qhsftdHfxmZN-ojp3smm-zzimuXcnI-WLZ6UP74A9Dxv5b1gN3vLFEYedF5yNaq-hG7Nzq57NA4qsfspy_jtd27Hiws4KUIdIdQN6YGqDgFKO0HJheu3Rq8P1AXX08VeGgKsvIbmA12QDVAZUE0Bc1k8NAd32HsM-VB1QbQFIW9vmcK_YsG5qpeUvGFq6aEq0AAIDv0vQc88Ez5BDRHbYSMaw9FTassfZcMInuNX9j91lKZWPOEHU12D8fTsOsNESohZBsqm8k8LnkkKlnmqUkyZaWVueZCpxRerNDOUkobST5wanLBbRVxg7OkNLkVT9l6vairLQZJEpea5ySbNrFaq0jpxMpU6VRkJlMBe4e7VHRnuylc2D7mhRvErSu6rQvYTi9JxRcPFfKPuW97USvwPFOQRtXVYtlQW1B6YUK3NWDPvAyuqMU5OtOZjAK2fV0oV98j5xGTi-9c34Dx20wbd2DwBILQPr_lYt-wO9PD-ayY7e1_esHuohk59IX-L9l6e7msXqGp1urX7nD-AnlMPHk
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9QwDLemISF44PujfBppSOyhR9O06fXxdOy0wTYhjaG9VUmTTIOpN609BPzH-y8WJ-0xYELjNY1cR7ETO7Z_BlhLxZgrkTrvRGseZzYtY6W5jVmmVaYNr62mB_2dXbG5n70_yA9WIB9qYRwTraPU-iA-afWJtj3CAHtL41-krUdjEh4quL6WF8xHZyfTveUBTJjtIbODxWNnH_TRycso0J1Ut7_fSX8ZmpfeSf7-md2Gz0vOfdrJ19GiU6P65x-gjv-9tDtwq7dIcRJE6C6smOYe3JwcnvaoHOY-nIVyXtu_7-Hcojsckc4S6srUIhWpIKX_4OzYt13DN3vy-NuRxABRQdZ-i9ujdZQtUnkQTXHmMgYIjx84DRnzKBuNziTFraF3Cv2LBnZks6AiDF9Vib8CAujYoe8D8EFgKiSieWoTx7gKkNS0yjp0yyCyF_jFje8dlYu1D2B_tvFpuhn3PSJiybnoYmkLUaY1S7gRdZnrrJBWWFEqxlVOYUbj7C0plRbkC-e65MyahGk3SwhdWv4QVpt5Yx4DZllaK1aSjNrMKiUTqTIrcqlyXuhCRvDa7VLV63hb-fB9yio_6Lau6rcugvVBmqqTABnyj7mvBnGrnF5TsEY2Zr5oqT0ovTQ59zWCR0EOl9TS0jnVhUgiWLsomMvvifeMydX3LnAE7CrTpj0oPIEhdE-uuNiXcP3ju1m1vbX74SnccNbkONT7P4PV7nRhnjuLrVMvvH6eA1L7PvM
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identification+of+New+Compounds+from+Sage+Flowers+%28Salvia+officinalis+L.%29+as+Markers+for+Quality+Control+and+the+Influence+of+the+Manufacturing+Technology+on+the+Chemical+Composition+and+Antibacterial+Activity+of+Sage+Flower+Extracts&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.au=Gericke%2C+Sebastian&rft.au=Luebken%2C+Tilo&rft.au=Wolf%2C+Diana&rft.au=Kaiser%2C+Martin&rft.date=2018-02-28&rft.pub=Amer+Chemical+Soc&rft.issn=0021-8561&rft.eissn=1520-5118&rft.volume=66&rft.issue=8&rft.spage=1843&rft.epage=1853&rft_id=info:doi/10.1021%2Facs.jafc.8b00581&rft_id=info%3Apmid%2F29448760&rft.externalDBID=n%2Fa&rft.externalDocID=000426614400014
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-8561&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-8561&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-8561&client=summon