Identification of New Compounds from Sage Flowers (Salvia officinalis L.) as Markers for Quality Control and the Influence of the Manufacturing Technology on the Chemical Composition and Antibacterial Activity of Sage Flower Extracts

Parts of Salvia species such as its flowers and leaves are currently used as a culinary herb and for some medicinal applications. To distinguish the different sage extracts it is necessary to analyze their individual chemical compositions. Their characteristic compounds might be established as marke...

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Bibliographic Details
Published inJournal of agricultural and food chemistry Vol. 66; no. 8; pp. 1843 - 1853
Main Authors Gericke, Sebastian, Lübken, Tilo, Wolf, Diana, Kaiser, Martin, Hannig, Christian, Speer, Karl
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 28.02.2018
Amer Chemical Soc
Subjects
Agriculture
Agriculture, Multidisciplinary
Chemistry
Chemistry, Applied
Food Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Science & Technology
flowers
sage flower resin
caffeic acid ethyl ester
manufacturing technology
marker
salvia
salviquinone A
tri-p-coumaroylspermidine
salviquinone B
antibacterial activities
SPERMIDINE
GALDOSOL
IN-VITRO
POLYPHENOLS
ROSMARINUS-OFFICINALIS
ABIETANE DITERPENES
PHENOLIC DITERPENES
CONSTITUENTS
AMIDES
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Summary:Parts of Salvia species such as its flowers and leaves are currently used as a culinary herb and for some medicinal applications. To distinguish the different sage extracts it is necessary to analyze their individual chemical compositions. Their characteristic compounds might be established as markers to differentiate between sage flowers and leaf extracts or to determine the manufacturing technology and storage conditions. Tri-p-coumaroylspermidine can be detected only in flowers and has been described here for Salvia and Lavandula species for the first time. Markers for oxidation processes are the novel compounds salviquinone A and B, which were generated from carnosol by exposure to oxygen. Caffeic acid ethyl ester was established as an indirect marker for the usage of ethanol as extraction solvent. The compounds were identified by LC-QTOF-HRESIMS, LC-MS, NMR, IR, and single-crystal X-ray diffraction after isolation by semipreparative HPLC. Furthermore, sage flower resin showed interesting antibacterial in vitro activities against Gram-positive and Gram-negative bacteria.
Bibliography:ObjectType-Article-1
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ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.8b00581