Technetium in Cryogenic Cerebral Injury and Edema

• Published in: Archives of neurology (Chicago) Vol. 27; no. 6; pp. 526 - 534
• Main Authors: Hindo, Walid A, Clasen, Raymond A, Rayudu, Garimella V. S, Pandolfi, Sylvia
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 01.12.1972
• Subjects: Animals; Brain - metabolism; Brain Edema - etiology; Brain Edema - metabolism; Brain Injuries - complications; Brain Injuries - metabolism; Brain Neoplasms - metabolism; Cerebrospinal Fluid Proteins; Cerebrovascular Disorders - metabolism; Chelating Agents; Chlorides - blood; Chlorides - cerebrospinal fluid; Copper - metabolism; Cryosurgery; Dogs; Edetic Acid - metabolism; Humans; Indium - metabolism; Radioisotopes - metabolism; Radionuclide Imaging; Serum Albumin - analysis; Technetium - blood; Technetium - cerebrospinal fluid; Technetium - metabolism
• ISSN: 0003-9942; 1538-3687
• DOI: 10.1001/archneur.1972.00490180062014

The distribution of technetium given as the pertechnetate ion and as the diethylenetriaminepentacetic acid chelate was studied in the brains of dogs with cryogenic lesions. There was more of the chelate than the free form in the necrotic lesion. The radioactivity of the tissue, four hours after injection of the isotope, was compared to the values at 15 minutes. The greatest increase in radioactivity was found in the edema fluid but the concentration of the isotope in both forms was significantly less than that in the serum. The experimental model was then compared to human disease. It was concluded that a scan at four hours should be superior to a 15-minute scan and that a careful comparison of early and late scans could give a quantitative measure of the edema surrounding brain tumors.