Developments in the Catalytic Asymmetric Synthesis of Agrochemicals and Their Synthetic Importance

Catalytic asymmetric synthesis has become an essential tool for the enantioselective synthesis of pharmaceuticals, natural products, and agrochemicals (mainly fungicides, herbicides, insecticides, and pheromones). With continuous growing interest in both modern agricultural chemistry and catalytic a...

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Published inJournal of agricultural and food chemistry Vol. 69; no. 49; pp. 14761 - 14780
Main Authors Sharma, Sandeep Kumar, Paniraj, Alilugatta Sheshagiri Rao, Tambe, Yashwant Bhikaji
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 15.12.2021
Subjects
Agrochemicals
Biological Products
Catalysis
Crop Protection
Fungicides, Industrial
chiral
agrochemicals
pheromones
insecticides
catalytic asymmetric synthesis
herbicides
enantioselective
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Summary:Catalytic asymmetric synthesis has become an essential tool for the enantioselective synthesis of pharmaceuticals, natural products, and agrochemicals (mainly fungicides, herbicides, insecticides, and pheromones). With continuous growing interest in both modern agricultural chemistry and catalytic asymmetric synthesis chemistry, this review provides a comprehensive overview of some earlier reports as well as the recent successful applications of various catalytic asymmetric syntheses methodologies, such as enantioselective hydroformylation, enantioselective hydrogenation, asymmetric Sharpless epoxidation and dihydroxylation, asymmetric cyclopropanation or isomerization, organocatalyzed asymmetric synthesis, and so forth, which have been used as key steps in the preparation of chiral agrochemicals (on R&D, piloting, and commercial scales). Chiral agrochemicals can also lead the new generation of such chemicals having specific and novel modes of action for achieving sustainable crop protection and production. Some perspectives and challenges for these catalytic asymmetric methodologies in the synthesis of chiral agrochemicals are also briefly discussed in the final section of the manuscript. This review will provide the insight regarding understanding, development, and evaluation of catalytic asymmetric systems for the synthesis of chiral agrochemicals among the agrochemists.
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ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.1c05553