The incidence of decreased red blood cell deformability in sepsis and the association with oxygen free radical damage and multiple-system organ failure

We studied the incidence of decreased red blood cell deformability (RBCD) in sepsis and the association between decreased RBCD and oxygen free radical generation (as measured by malonyldialdehyde) and the occurrence of multiple-system organ failure (MSOF). Patients were divided into three groups: se...

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Bibliographic Details
Published inArchives of surgery (Chicago. 1960) Vol. 124; no. 12; p. 1386
Main Authors Machiedo, G W, Powell, R J, Rush, Jr, B F, Swislocki, N I, Dikdan, G
Format Journal Article
LanguageEnglish
Published United States 01.12.1989
Subjects
Adult
Erythrocyte Deformability
Free Radicals
Humans
Infection - blood
Infection - complications
Malondialdehyde - blood
Middle Aged
Multiple Organ Failure - blood
Multiple Organ Failure - etiology
Multiple Organ Failure - metabolism
Oxygen - metabolism
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Summary:We studied the incidence of decreased red blood cell deformability (RBCD) in sepsis and the association between decreased RBCD and oxygen free radical generation (as measured by malonyldialdehyde) and the occurrence of multiple-system organ failure (MSOF). Patients were divided into three groups: septic (n = 28), nonseptic (n = 15), and control (n = 5). Serial measurements of deformability index, malonyldialdehyde, and MSOF were made. The deformability index for the septic group (0.23 +/- 0.17) was significantly less than that for the nonseptic (1.12 +/- 0.48) and control (1.11 +/- 0.25) groups. The malonyldialdehyde levels for the septic group (4.5 +/- 1.0 nmol/mL) were significantly greater than those for the nonseptic (2.7 +/- 0.9 nmol/mL) and control (2.6 +/- 0.8 nmol/mL) groups. The MSOF index for the septic group (10.1 +/- 2.5) was significantly greater than that for the nonseptic (7.6 +/- 1.7) and control (6.0 +/- 0.0) groups. An inverse correlation existed between malonyldialdehyde and deformability index ( = .501, less than .001, n = 40) and between deformability index and MSOF index (= .350, less than .05, n = 61). We conclude that RBCD is decreased during human sepsis; free radicals generated during sepsis may play a role in the decrease in RBCD. Decreased RBCD may contribute to the MSOF that occurs during sepsis.
ISSN:0004-0010
DOI:10.1001/archsurg.1989.01410120032007