Hemodynamic Studies Within the Brain During Migraine

Using the intracarotid xenon Xe 133 clearance method for determination of regional blood flow within the internal carotid area, we examined four patients during the prodromal phase of migraine. They all showed a severely reduced perfusion, in some areas to a level known to be critical for an adequat...

Full description

Saved in:
Bibliographic Details
Published inArchives of neurology (Chicago) Vol. 29; no. 2; pp. 95 - 98
Main Author Skinhoj, E
Format Journal Article
LanguageEnglish
Published United States American Medical Association 01.08.1973
Subjects
Adult
Basilar Artery - physiopathology
Bicarbonates - cerebrospinal fluid
Brain - metabolism
Carbon Dioxide - blood
Carotid Arteries - physiopathology
Carotid Artery, Internal - physiopathology
Cerebral Angiography
Cerebrovascular Circulation
Female
Humans
Lactates - metabolism
Male
Middle Aged
Migraine Disorders - etiology
Migraine Disorders - metabolism
Migraine Disorders - physiopathology
Oxygen - blood
Perfusion
Xenon
Online AccessGet full text

Cover

More Information
Summary:Using the intracarotid xenon Xe 133 clearance method for determination of regional blood flow within the internal carotid area, we examined four patients during the prodromal phase of migraine. They all showed a severely reduced perfusion, in some areas to a level known to be critical for an adequate oxygenation. Six patients examined during the headache phase showed a significant hyperperfusion. As a possible cause of this hyperperfusion, an intracerebral lactate-acidosis was found in all cases, indicating that even common migraine is preceeded by a subclinical cerebral hypoxia. Angiographic studies during the prodromal phase support the hypothesis that vascular dysregulation in the basilar artery, as well as in the carotids, play a substantial role in the pathogenesis of migraine.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0003-9942
1538-3687
DOI:10.1001/archneur.1973.00490260039007