Impact of Red Yeast Rice on Metabolic Diseases: A Review of Possible Mechanisms of Action

• Published in: Journal of agricultural and food chemistry Vol. 68; no. 39; pp. 10441 - 10455
• Main Authors: Hu, Ju, Wang, Jin, Gan, Qing-xia, Ran, Qian, Lou, Guan-hua, Xiong, Hai-jun, Peng, Cheng-yi, Sun, Ji-lin, Yao, Ren-chuan, Huang, Qin-wan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 30.09.2020
• Subjects: Animals; Biological Products - administration & dosage; Dietary Supplements - analysis; Humans; Metabolic Diseases - drug therapy; Metabolic Diseases - metabolism; multiple pathways; multiple targets; metabolic diseases; red yeast rice
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/acs.jafc.0c01893

Metabolic diseases constitute a major public health burden and are linked with high morbidity and mortality. They comprise atherosclerosis dyslipidemia, diabetes, hypertension, and obesity. However, there is no single drug that can simultaneously treat multiple diseases with complex underlying mechanisms. Therefore, it is necessary to identify a class of adjuvant drugs that block the development of metabolic diseases from a preventive perspective. Red yeast rice is a food fermentation product widely used to promote blood circulation and remove blood stasis. Modern pharmacology has shown that red yeast rice exerts potential protective effects on the liver, pancreas, blood vessels, and intestines. Therefore, this study was carried out to analyze and summarize the effect of red yeast rice on several metabolic diseases and the mechanisms of action involved. It was found that red yeast rice may be beneficial in the prevention and treatment of metabolic diseases.