New Benzophenones and Xanthones from Cratoxylum sumatranum ssp. neriifolium and Their Antibacterial and Antioxidant Activities

• Published in: Journal of agricultural and food chemistry Vol. 64; no. 46; pp. 8755 - 8762
• Main Authors: Tantapakul, Cholpisut, Maneerat, Wisanu, Sripisut, Tawanun, Ritthiwigrom, Thunwadee, Andersen, Raymond J, Cheng, Ping, Cheenpracha, Sarot, Raksat, Achara, Laphookhieo, Surat
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 23.11.2016; Amer Chemical Soc
• Subjects: Agriculture; Agriculture, Multidisciplinary; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Bacillus cereus - drug effects; Benzophenones - chemistry; Benzophenones - pharmacology; Chemistry; Chemistry, Applied; Clusiaceae - chemistry; Food Science & Technology; Life Sciences & Biomedicine; Microbial Sensitivity Tests; Molecular Structure; Physical Sciences; Plant Extracts - chemistry; Plant Extracts - pharmacology; Pseudomonas aeruginosa - drug effects; Science & Technology; Staphylococcus aureus - drug effects; Xanthones - chemistry; Xanthones - pharmacology; antibacterial activity; Cratoxylum sumatranum ssp. neriifolium; benzophenone; antioxidant activity; xanthone; PHLOROGLUCINOL; PHENOLIC-COMPOUNDS; CYTOTOXIC XANTHONES; Cratoxylum sumatranum ssp neriifolium; FORMOSUM; STEMS; BIOACTIVE PRENYLATED XANTHONES; COCHINCHINENSE; ROOTS; DERIVATIVES; CONSTITUENTS
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/acs.jafc.6b03643

Two new benzophenones (1 and 2) and four new xanthones (4–6 and 17) together with 24 known compounds (3, 7–16, and 18–30) were isolated from the roots and twigs of Cratoxylum sumatranum ssp. neriifolium. Their structures were elucidated by spectroscopic methods. Compounds 5 and 26 showed antibacterial activity against Micrococcus luteus, Bacillus cereus, and Staphylococcus epidermis with minimum inhibitory concentrations ranging from 4 to 8 μg/mL, whereas compounds 7, 20, and 26 displayed selective antibacterial activities against Staphylococcus aureus (8 μg/mL), Salmonella typhimurium (4 μg/mL), and Pseudomonas aeruginosa (4 μg/mL), respectively. The radical scavenging effects of some isolated compounds were investigated. Compounds 11 and 21 exhibited potent activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) with IC50 values of 7.0 ± 1.0 and 6.0 ± 0.2 μM, respectively.