Highly E‑Selective Synthesis of α‑Fluoro-β-arylalkenyl Sulfones from gem-Difluoroalkenes with Sodium Sulfinates

The straightforward synthesis of α-fluoro-β-arylalkenyl sulfones under transition-metal- and base-free conditions has been described, which displays broad functional group compatibility and high stereoselectivity. In particular, the strategy is also applied to the late-stage modification of complex...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 86; no. 9; pp. 6983 - 6993
Main Authors Li, Yuxiu, Li, Xiangqian, Li, Xiaowei, Shi, Dayong
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 07.05.2021
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
FUNCTIONALIZATION
ALKENES
ROUTE
VINYL SULFONES
CONSTRUCTION
INHIBITORS
CENTERS
C-F
F BOND ACTIVATION
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Summary:The straightforward synthesis of α-fluoro-β-arylalkenyl sulfones under transition-metal- and base-free conditions has been described, which displays broad functional group compatibility and high stereoselectivity. In particular, the strategy is also applied to the late-stage modification of complex natural products and drugs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c00490