One-Pot Synthesis of α‑Ketoamides from α‑Keto Acids and Amines Using Ynamides as Coupling Reagents

A one-pot strategy for α-keto amide bond formation have been developed by using ynamides as coupling reagents under extremely mild reaction conditions. Diversely structural α-ketoamides were afforded in up to 98% yield for 36 examples. This reaction features advantages such as practical coupling pro...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 87; no. 5; pp. 3661 - 3667
Main Authors Ma, Jianting, Cui, Xue, Xu, Junyu, Tan, Yinfeng, Wang, Yan, Wang, Xuesong, Li, Youbin
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 04.03.2022
Subjects
Amines - chemistry
Indicators and Reagents
Keto Acids
Oxidation-Reduction
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Summary:A one-pot strategy for α-keto amide bond formation have been developed by using ynamides as coupling reagents under extremely mild reaction conditions. Diversely structural α-ketoamides were afforded in up to 98% yield for 36 examples. This reaction features advantages such as practical coupling procedure, wide functional group tolerance, and extremely mild conditions and has potential applications in synthetic and medicinal chemistry.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c02453